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Identification of a novel class of orally active pyrimido[5,4-3][1,2,4]triazine-5,7-diamine-based hypoglycemic agents with protein tyrosine phosphatase inhibitory activity.
Guertin KR, Setti L, Qi L, Dunsdon RM, Dymock BW, Jones PS, Overton H, Taylor M, Williams G, Sergi JA, Wang K, Peng Y, Renzetti M, Boyce R, Falcioni F, Garippa R, Olivier AR. Guertin KR, et al. Among authors: sergi ja. Bioorg Med Chem Lett. 2003 Sep 1;13(17):2895-8. doi: 10.1016/s0960-894x(03)00623-1. Bioorg Med Chem Lett. 2003. PMID: 14611852
A selective phosphatase of regenerating liver phosphatase inhibitor suppresses tumor cell anchorage-independent growth by a novel mechanism involving p130Cas cleavage.
Daouti S, Li WH, Qian H, Huang KS, Holmgren J, Levin W, Reik L, McGady DL, Gillespie P, Perrotta A, Bian H, Reidhaar-Olson JF, Bliss SA, Olivier AR, Sergi JA, Fry D, Danho W, Ritland S, Fotouhi N, Heimbrook D, Niu H. Daouti S, et al. Among authors: sergi ja. Cancer Res. 2008 Feb 15;68(4):1162-9. doi: 10.1158/0008-5472.CAN-07-2349. Cancer Res. 2008. PMID: 18281492
Discovery and Control of Succinimide Formation and Accumulation at Aspartic Acid Residues in The Complementarity-Determining Region of a Therapeutic Monoclonal Antibody.
VanAernum ZL, Sergi JA, Dey M, Toner T, Kilgore B, Lay-Fortenbery A, Wang Y, Bian S, Kochert BA, Bothe JR, Gao X, Richardson D, Schuessler HA. VanAernum ZL, et al. Among authors: sergi ja. Pharm Res. 2023 Jun;40(6):1411-1423. doi: 10.1007/s11095-022-03462-0. Epub 2023 Jan 10. Pharm Res. 2023. PMID: 36627449