Santos KF - Search Results

1

The Prp8 RNase H-like domain inhibits Brr2-mediated U4/U6 snRNA unwinding by blocking Brr2 loading onto the U4 snRNA.

Mozaffari-Jovin S, Santos KF, Hsiao HH, Will CL, Urlaub H, Wahl MC, Lührmann R. Mozaffari-Jovin S, et al. Among authors: santos kf. Genes Dev. 2012 Nov 1;26(21):2422-34. doi: 10.1101/gad.200949.112. Genes Dev. 2012. PMID: 23124066 Free PMC article.

2

Mechanism for Aar2p function as a U5 snRNP assembly factor.

Weber G, Cristão VF, de L Alves F, Santos KF, Holton N, Rappsilber J, Beggs JD, Wahl MC. Weber G, et al. Among authors: santos kf. Genes Dev. 2011 Aug 1;25(15):1601-12. doi: 10.1101/gad.635911. Epub 2011 Jul 15. Genes Dev. 2011. PMID: 21764848 Free PMC article.

3

Structural basis for functional cooperation between tandem helicase cassettes in Brr2-mediated remodeling of the spliceosome.

Santos KF, Jovin SM, Weber G, Pena V, Lührmann R, Wahl MC. Santos KF, et al. Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):17418-23. doi: 10.1073/pnas.1208098109. Epub 2012 Oct 8. Proc Natl Acad Sci U S A. 2012. PMID: 23045696 Free PMC article.

4

Structural basis for dual roles of Aar2p in U5 snRNP assembly.

Weber G, Cristão VF, Santos KF, Jovin SM, Heroven AC, Holton N, Lührmann R, Beggs JD, Wahl MC. Weber G, et al. Among authors: santos kf. Genes Dev. 2013 Mar 1;27(5):525-40. doi: 10.1101/gad.213207.113. Epub 2013 Feb 26. Genes Dev. 2013. PMID: 23442228 Free PMC article.

5

Inhibition of RNA helicase Brr2 by the C-terminal tail of the spliceosomal protein Prp8.

Mozaffari-Jovin S, Wandersleben T, Santos KF, Will CL, Lührmann R, Wahl MC. Mozaffari-Jovin S, et al. Among authors: santos kf. Science. 2013 Jul 5;341(6141):80-4. doi: 10.1126/science.1237515. Epub 2013 May 23. Science. 2013. PMID: 23704370

6

Novel regulatory principles of the spliceosomal Brr2 RNA helicase and links to retinal disease in humans.

Mozaffari-Jovin S, Wandersleben T, Santos KF, Will CL, Lührmann R, Wahl MC. Mozaffari-Jovin S, et al. Among authors: santos kf. RNA Biol. 2014;11(4):298-312. doi: 10.4161/rna.28353. Epub 2014 Mar 5. RNA Biol. 2014. PMID: 24643059 Free PMC article. Review.

7

A noncanonical PWI domain in the N-terminal helicase-associated region of the spliceosomal Brr2 protein.

Absmeier E, Rosenberger L, Apelt L, Becke C, Santos KF, Stelzl U, Wahl MC. Absmeier E, et al. Among authors: santos kf. Acta Crystallogr D Biol Crystallogr. 2015 Apr;71(Pt 4):762-71. doi: 10.1107/S1399004715001005. Epub 2015 Mar 26. Acta Crystallogr D Biol Crystallogr. 2015. PMID: 25849387

8

A composite double-/single-stranded RNA-binding region in protein Prp3 supports tri-snRNP stability and splicing.

Liu S, Mozaffari-Jovin S, Wollenhaupt J, Santos KF, Theuser M, Dunin-Horkawicz S, Fabrizio P, Bujnicki JM, Lührmann R, Wahl MC. Liu S, et al. Among authors: santos kf. Elife. 2015 Jul 10;4:e07320. doi: 10.7554/eLife.07320. Elife. 2015. PMID: 26161500 Free PMC article.

9

Crystallization and biochemical characterization of the human spliceosomal Aar2-Prp8(RNaseH) complex.

Santos K, Preussner M, Heroven AC, Weber G. Santos K, et al. Acta Crystallogr F Struct Biol Commun. 2015 Nov;71(Pt 11):1421-8. doi: 10.1107/S2053230X15019202. Epub 2015 Oct 23. Acta Crystallogr F Struct Biol Commun. 2015. PMID: 26527271 Free PMC article.

10

The large N-terminal region of the Brr2 RNA helicase guides productive spliceosome activation.

Absmeier E, Wollenhaupt J, Mozaffari-Jovin S, Becke C, Lee CT, Preussner M, Heyd F, Urlaub H, Lührmann R, Santos KF, Wahl MC. Absmeier E, et al. Among authors: santos kf. Genes Dev. 2015 Dec 15;29(24):2576-87. doi: 10.1101/gad.271528.115. Epub 2015 Dec 4. Genes Dev. 2015. PMID: 26637280 Free PMC article.

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