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Page 1
Optimization and structure-activity relationships of a series of potent inhibitors of methicillin-resistant Staphylococcus aureus (MRSA) pyruvate kinase as novel antimicrobial agents.
Kumar NS, Amandoron EA, Cherkasov A, Finlay BB, Gong H, Jackson L, Kaur S, Lian T, Moreau A, Labrière C, Reiner NE, See RH, Strynadka NC, Thorson L, Wong EW, Worrall L, Zoraghi R, Young RN. Kumar NS, et al. Among authors: see rh. Bioorg Med Chem. 2012 Dec 15;20(24):7069-82. doi: 10.1016/j.bmc.2012.10.002. Epub 2012 Oct 17. Bioorg Med Chem. 2012. PMID: 23141418
Identification of pyruvate kinase in methicillin-resistant Staphylococcus aureus as a novel antimicrobial drug target.
Zoraghi R, See RH, Axerio-Cilies P, Kumar NS, Gong H, Moreau A, Hsing M, Kaur S, Swayze RD, Worrall L, Amandoron E, Lian T, Jackson L, Jiang J, Thorson L, Labriere C, Foster L, Brunham RC, McMaster WR, Finlay BB, Strynadka NC, Cherkasov A, Young RN, Reiner NE. Zoraghi R, et al. Among authors: see rh. Antimicrob Agents Chemother. 2011 May;55(5):2042-53. doi: 10.1128/AAC.01250-10. Epub 2011 Feb 28. Antimicrob Agents Chemother. 2011. PMID: 21357306 Free PMC article.
Methicillin-resistant Staphylococcus aureus (MRSA) pyruvate kinase as a target for bis-indole alkaloids with antibacterial activities.
Zoraghi R, Worrall L, See RH, Strangman W, Popplewell WL, Gong H, Samaai T, Swayze RD, Kaur S, Vuckovic M, Finlay BB, Brunham RC, McMaster WR, Davies-Coleman MT, Strynadka NC, Andersen RJ, Reiner NE. Zoraghi R, et al. Among authors: see rh. J Biol Chem. 2011 Dec 30;286(52):44716-25. doi: 10.1074/jbc.M111.289033. Epub 2011 Oct 26. J Biol Chem. 2011. PMID: 22030393 Free PMC article.
Cheminformatics-driven discovery of selective, nanomolar inhibitors for staphylococcal pyruvate kinase.
Axerio-Cilies P, See RH, Zoraghi R, Worral L, Lian T, Stoynov N, Jiang J, Kaur S, Jackson L, Gong H, Swayze R, Amandoron E, Kumar NS, Moreau A, Hsing M, Strynadka NC, McMaster WR, Finlay BB, Foster LJ, Young RN, Reiner NE, Cherkasov A. Axerio-Cilies P, et al. Among authors: see rh. ACS Chem Biol. 2012 Feb 17;7(2):350-9. doi: 10.1021/cb2003576. Epub 2011 Nov 21. ACS Chem Biol. 2012. PMID: 22066782
Mapping the protein interaction network in methicillin-resistant Staphylococcus aureus.
Cherkasov A, Hsing M, Zoraghi R, Foster LJ, See RH, Stoynov N, Jiang J, Kaur S, Lian T, Jackson L, Gong H, Swayze R, Amandoron E, Hormozdiari F, Dao P, Sahinalp C, Santos-Filho O, Axerio-Cilies P, Byler K, McMaster WR, Brunham RC, Finlay BB, Reiner NE. Cherkasov A, et al. Among authors: see rh. J Proteome Res. 2011 Mar 4;10(3):1139-50. doi: 10.1021/pr100918u. Epub 2011 Jan 28. J Proteome Res. 2011. PMID: 21166474
Synergistic effects of baicalein with ciprofloxacin against NorA over-expressed methicillin-resistant Staphylococcus aureus (MRSA) and inhibition of MRSA pyruvate kinase.
Chan BC, Ip M, Lau CB, Lui SL, Jolivalt C, Ganem-Elbaz C, Litaudon M, Reiner NE, Gong H, See RH, Fung KP, Leung PC. Chan BC, et al. Among authors: see rh. J Ethnopharmacol. 2011 Sep 1;137(1):767-73. doi: 10.1016/j.jep.2011.06.039. Epub 2011 Jul 1. J Ethnopharmacol. 2011. PMID: 21782012
34 results