Moore CD - Search Results

1

Metabolic pathways of inhaled glucocorticoids by the CYP3A enzymes.

Moore CD, Roberts JK, Orton CR, Murai T, Fidler TP, Reilly CA, Ward RM, Yost GS. Moore CD, et al. Drug Metab Dispos. 2013 Feb;41(2):379-89. doi: 10.1124/dmd.112.046318. Epub 2012 Nov 9. Drug Metab Dispos. 2013. PMID: 23143891 Free PMC article.

2

Respective roles of CYP2A5 and CYP2F2 in the bioactivation of 3-methylindole in mouse olfactory mucosa and lung: studies using Cyp2a5-null and Cyp2f2-null mouse models.

Zhou X, D'Agostino J, Li L, Moore CD, Yost GS, Ding X. Zhou X, et al. Among authors: moore cd. Drug Metab Dispos. 2012 Apr;40(4):642-7. doi: 10.1124/dmd.111.044081. Epub 2012 Jan 6. Drug Metab Dispos. 2012. PMID: 22228748 Free PMC article.

3

Metabolism of beclomethasone dipropionate by cytochrome P450 3A enzymes.

Roberts JK, Moore CD, Ward RM, Yost GS, Reilly CA. Roberts JK, et al. Among authors: moore cd. J Pharmacol Exp Ther. 2013 May;345(2):308-16. doi: 10.1124/jpet.112.202556. Epub 2013 Mar 19. J Pharmacol Exp Ther. 2013. PMID: 23512537 Free PMC article.

4

Regulation of CYP3A genes by glucocorticoids in human lung cells.

Roberts JK, Moore CD, Romero EG, Ward RM, Yost GS, Reilly CA. Roberts JK, et al. Among authors: moore cd. F1000Res. 2013 Aug 13;2:173. doi: 10.12688/f1000research.2-173.v2. eCollection 2013. F1000Res. 2013. PMID: 24555085 Free PMC article.

5

CYP3A4-Mediated oxygenation versus dehydrogenation of raloxifene.

Moore CD, Reilly CA, Yost GS. Moore CD, et al. Biochemistry. 2010 Jun 1;49(21):4466-75. doi: 10.1021/bi902213r. Biochemistry. 2010. PMID: 20405834 Free PMC article.

6

Improved cytochrome P450 3A4 molecular models accurately predict the Phe215 requirement for raloxifene dehydrogenation selectivity.

Moore CD, Shahrokh K, Sontum SF, Cheatham TE 3rd, Yost GS. Moore CD, et al. Biochemistry. 2010 Oct 19;49(41):9011-9. doi: 10.1021/bi101139q. Biochemistry. 2010. PMID: 20812728 Free PMC article.

7

Dehydrogenation of the indoline-containing drug 4-chloro-N-(2-methyl-1-indolinyl)-3-sulfamoylbenzamide (indapamide) by CYP3A4: correlation with in silico predictions.

Sun H, Moore C, Dansette PM, Kumar S, Halpert JR, Yost GS. Sun H, et al. Drug Metab Dispos. 2009 Mar;37(3):672-84. doi: 10.1124/dmd.108.022707. Epub 2008 Dec 12. Drug Metab Dispos. 2009. PMID: 19074530 Free PMC article.

8

3-Methylindole is mutagenic and a possible pulmonary carcinogen.

Weems JM, Cutler NS, Moore C, Nichols WK, Martin D, Makin E, Lamb JG, Yost GS. Weems JM, et al. Toxicol Sci. 2009 Nov;112(1):59-67. doi: 10.1093/toxsci/kfp201. Epub 2009 Aug 21. Toxicol Sci. 2009. PMID: 19700606 Free PMC article.

9

Directed evolution reveals requisite sequence elements in the functional expression of P450 2F1 in Escherichia coli.

Behrendorff JB, Moore CD, Kim KH, Kim DH, Smith CA, Johnston WA, Yun CH, Yost GS, Gillam EM. Behrendorff JB, et al. Among authors: moore cd. Chem Res Toxicol. 2012 Sep 17;25(9):1964-74. doi: 10.1021/tx300281g. Epub 2012 Aug 29. Chem Res Toxicol. 2012. PMID: 22901340 Free PMC article.

10

Studies of styrene, styrene oxide and 4-hydroxystyrene toxicity in CYP2F2 knockout and CYP2F1 humanized mice support lack of human relevance for mouse lung tumors.

Cruzan G, Bus J, Hotchkiss J, Sura R, Moore C, Yost G, Banton M, Sarang S. Cruzan G, et al. Regul Toxicol Pharmacol. 2013 Jun;66(1):24-9. doi: 10.1016/j.yrtph.2013.02.008. Epub 2013 Feb 27. Regul Toxicol Pharmacol. 2013. PMID: 23454103

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