Benedek GB - Search Results

1

C-terminal turn stability determines assembly differences between Aβ40 and Aβ42.

Roychaudhuri R, Yang M, Deshpande A, Cole GM, Frautschy S, Lomakin A, Benedek GB, Teplow DB. Roychaudhuri R, et al. Among authors: benedek gb. J Mol Biol. 2013 Jan 23;425(2):292-308. doi: 10.1016/j.jmb.2012.11.006. Epub 2012 Nov 12. J Mol Biol. 2013. PMID: 23154165 Free PMC article.

2

Gly25-Ser26 amyloid β-protein structural isomorphs produce distinct Aβ42 conformational dynamics and assembly characteristics.

Roychaudhuri R, Lomakin A, Bernstein S, Zheng X, Condron MM, Benedek GB, Bowers M, Teplow DB. Roychaudhuri R, et al. Among authors: benedek gb. J Mol Biol. 2014 Jun 26;426(13):2422-41. doi: 10.1016/j.jmb.2014.04.004. Epub 2014 Apr 13. J Mol Biol. 2014. PMID: 24735871 Free PMC article.

3

Role of Species-Specific Primary Structure Differences in Aβ42 Assembly and Neurotoxicity.

Roychaudhuri R, Zheng X, Lomakin A, Maiti P, Condron MM, Benedek GB, Bitan G, Bowers MT, Teplow DB. Roychaudhuri R, et al. Among authors: benedek gb. ACS Chem Neurosci. 2015 Dec 16;6(12):1941-55. doi: 10.1021/acschemneuro.5b00180. Epub 2015 Oct 19. ACS Chem Neurosci. 2015. PMID: 26421877 Free PMC article.

4

C-terminal peptides coassemble into Abeta42 oligomers and protect neurons against Abeta42-induced neurotoxicity.

Fradinger EA, Monien BH, Urbanc B, Lomakin A, Tan M, Li H, Spring SM, Condron MM, Cruz L, Xie CW, Benedek GB, Bitan G. Fradinger EA, et al. Among authors: benedek gb. Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):14175-80. doi: 10.1073/pnas.0807163105. Epub 2008 Sep 8. Proc Natl Acad Sci U S A. 2008. PMID: 18779585 Free PMC article.

5

Despite its role in assembly, methionine 35 is not necessary for amyloid beta-protein toxicity.

Maiti P, Lomakin A, Benedek GB, Bitan G. Maiti P, et al. Among authors: benedek gb. J Neurochem. 2010 Jun;113(5):1252-62. doi: 10.1111/j.1471-4159.2010.06692.x. Epub 2010 Mar 20. J Neurochem. 2010. PMID: 20345758 Free PMC article.

6

Mechanistic investigation of the inhibition of Abeta42 assembly and neurotoxicity by Abeta42 C-terminal fragments.

Li H, Monien BH, Lomakin A, Zemel R, Fradinger EA, Tan M, Spring SM, Urbanc B, Xie CW, Benedek GB, Bitan G. Li H, et al. Among authors: benedek gb. Biochemistry. 2010 Aug 3;49(30):6358-64. doi: 10.1021/bi100773g. Biochemistry. 2010. PMID: 20568734 Free PMC article.

7

Amyloid beta -protein (Abeta) assembly: Abeta 40 and Abeta 42 oligomerize through distinct pathways.

Bitan G, Kirkitadze MD, Lomakin A, Vollers SS, Benedek GB, Teplow DB. Bitan G, et al. Among authors: benedek gb. Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):330-5. doi: 10.1073/pnas.222681699. Epub 2002 Dec 27. Proc Natl Acad Sci U S A. 2003. PMID: 12506200 Free PMC article.

8

Quasielastic light scattering for protein assembly studies.

Lomakin A, Teplow DB, Benedek GB. Lomakin A, et al. Among authors: benedek gb. Methods Mol Biol. 2005;299:153-74. doi: 10.1385/1-59259-874-9:153. Methods Mol Biol. 2005. PMID: 15980600

9

Lysine-specific molecular tweezers are broad-spectrum inhibitors of assembly and toxicity of amyloid proteins.

Sinha S, Lopes DH, Du Z, Pang ES, Shanmugam A, Lomakin A, Talbiersky P, Tennstaedt A, McDaniel K, Bakshi R, Kuo PY, Ehrmann M, Benedek GB, Loo JA, Klärner FG, Schrader T, Wang C, Bitan G. Sinha S, et al. Among authors: benedek gb. J Am Chem Soc. 2011 Oct 26;133(42):16958-69. doi: 10.1021/ja206279b. Epub 2011 Sep 29. J Am Chem Soc. 2011. PMID: 21916458 Free PMC article.

10

Amyloid beta-protein fibrillogenesis. Detection of a protofibrillar intermediate.

Walsh DM, Lomakin A, Benedek GB, Condron MM, Teplow DB. Walsh DM, et al. Among authors: benedek gb. J Biol Chem. 1997 Aug 29;272(35):22364-72. doi: 10.1074/jbc.272.35.22364. J Biol Chem. 1997. PMID: 9268388 Free article.

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