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LKB1; linking cell structure and tumor suppression.
Hezel AF, Bardeesy N. Hezel AF, et al. Among authors: bardeesy n. Oncogene. 2008 Nov 24;27(55):6908-19. doi: 10.1038/onc.2008.342. Oncogene. 2008. PMID: 19029933 Review.
Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner.
Kalender A, Selvaraj A, Kim SY, Gulati P, Brûlé S, Viollet B, Kemp BE, Bardeesy N, Dennis P, Schlager JJ, Marette A, Kozma SC, Thomas G. Kalender A, et al. Among authors: bardeesy n. Cell Metab. 2010 May 5;11(5):390-401. doi: 10.1016/j.cmet.2010.03.014. Cell Metab. 2010. PMID: 20444419 Free PMC article.
The Lkb1 metabolic sensor maintains haematopoietic stem cell survival.
Gurumurthy S, Xie SZ, Alagesan B, Kim J, Yusuf RZ, Saez B, Tzatsos A, Ozsolak F, Milos P, Ferrari F, Park PJ, Shirihai OS, Scadden DT, Bardeesy N. Gurumurthy S, et al. Among authors: bardeesy n. Nature. 2010 Dec 2;468(7324):659-63. doi: 10.1038/nature09572. Nature. 2010. PMID: 21124451 Free PMC article.
Erratum: Lkb1 inactivation drives lung cancer lineage switching governed by Polycomb Repressive Complex 2.
Zhang H, Brainson CF, Koyama S, Redig AJ, Chen T, Li S, Gupta M, Garcia-de-Alba C, Paschini M, Herter-Sprie GS, Lu G, Zhang X, Marsh BP, Tuminello SJ, Xu C, Chen Z, Wang X, Akbay EA, Zheng M, Palakurthi S, Sholl LM, Rustgi AK, Kwiatkowski DJ, Alan Diehl J, Bass AJ, Sharpless NE, Dranoff G, Hammerman PS, Ji H, Bardeesy N, Saur D, Watanabe H, Kim CF, Wong KK. Zhang H, et al. Among authors: bardeesy n. Nat Commun. 2017 Jun 9;8:15901. doi: 10.1038/ncomms15901. Nat Commun. 2017. PMID: 28598439 Free PMC article.
LKB1-AMPK axis revisited.
Kottakis F, Bardeesy N. Kottakis F, et al. Among authors: bardeesy n. Cell Res. 2012 Dec;22(12):1617-20. doi: 10.1038/cr.2012.108. Epub 2012 Jul 17. Cell Res. 2012. PMID: 22801477 Free PMC article.
The CRTC1-NEDD9 signaling axis mediates lung cancer progression caused by LKB1 loss.
Feng Y, Wang Y, Wang Z, Fang Z, Li F, Gao Y, Liu H, Xiao T, Li F, Zhou Y, Zhai Q, Liu X, Sun Y, Bardeesy N, Wong KK, Chen H, Xiong ZQ, Ji H. Feng Y, et al. Among authors: bardeesy n. Cancer Res. 2012 Dec 15;72(24):6502-11. doi: 10.1158/0008-5472.CAN-12-1909. Epub 2012 Oct 16. Cancer Res. 2012. PMID: 23074285 Free PMC article.
The LKB1 tumor suppressor as a biomarker in mouse and human tissues.
Nakada Y, Stewart TG, Peña CG, Zhang S, Zhao N, Bardeesy N, Sharpless NE, Wong KK, Hayes DN, Castrillon DH. Nakada Y, et al. Among authors: bardeesy n. PLoS One. 2013 Sep 25;8(9):e73449. doi: 10.1371/journal.pone.0073449. eCollection 2013. PLoS One. 2013. PMID: 24086281 Free PMC article.
mTORC1 activation blocks BrafV600E-induced growth arrest but is insufficient for melanoma formation.
Damsky W, Micevic G, Meeth K, Muthusamy V, Curley DP, Santhanakrishnan M, Erdelyi I, Platt JT, Huang L, Theodosakis N, Zaidi MR, Tighe S, Davies MA, Dankort D, McMahon M, Merlino G, Bardeesy N, Bosenberg M. Damsky W, et al. Among authors: bardeesy n. Cancer Cell. 2015 Jan 12;27(1):41-56. doi: 10.1016/j.ccell.2014.11.014. Cancer Cell. 2015. PMID: 25584893 Free PMC article.
LKB1 deficiency sensitizes mice to carcinogen-induced tumorigenesis.
Gurumurthy S, Hezel AF, Sahin E, Berger JH, Bosenberg MW, Bardeesy N. Gurumurthy S, et al. Among authors: bardeesy n. Cancer Res. 2008 Jan 1;68(1):55-63. doi: 10.1158/0008-5472.CAN-07-3225. Cancer Res. 2008. PMID: 18172296 Free PMC article.
238 results