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HLA-A*24 is an independent predictor of 5-year progression to diabetes in autoantibody-positive first-degree relatives of type 1 diabetic patients.
Mbunwe E, Van der Auwera BJ, Vermeulen I, Demeester S, Van Dalem A, Balti EV, Van Aken S, Derdelinckx L, Dorchy H, De Schepper J, van Schravendijk C, Wenzlau JM, Hutton JC, Pipeleers D, Weets I, Gorus FK; Belgian Diabetes Registry. Mbunwe E, et al. Among authors: van der auwera bj. Diabetes. 2013 Apr;62(4):1345-50. doi: 10.2337/db12-0747. Epub 2012 Nov 16. Diabetes. 2013. PMID: 23160529 Free PMC article.
Screening for insulitis in adult autoantibody-positive organ donors.
In't Veld P, Lievens D, De Grijse J, Ling Z, Van der Auwera B, Pipeleers-Marichal M, Gorus F, Pipeleers D. In't Veld P, et al. Diabetes. 2007 Sep;56(9):2400-4. doi: 10.2337/db07-0416. Epub 2007 Jun 11. Diabetes. 2007. PMID: 17563060 Free article.
Accelerated Progression to Type 1 Diabetes in the Presence of HLA-A*24 and -B*18 Is Restricted to Multiple Islet Autoantibody-Positive Individuals With Distinct HLA-DQ and Autoantibody Risk Profiles.
Balke EM, Balti EV, Van der Auwera B, Weets I, Costa O, Demeester S, Abrams P, Casteels K, Coeckelberghs M, Tenoutasse S, Keymeulen B, Pipeleers DG, Gorus FK; Belgian Diabetes Registry. Balke EM, et al. Diabetes Care. 2018 May;41(5):1076-1083. doi: 10.2337/dc17-2462. Epub 2018 Mar 15. Diabetes Care. 2018. PMID: 29545461
In antibody-positive first-degree relatives of patients with type 1 diabetes, HLA-A*24 and HLA-B*18, but not HLA-B*39, are predictors of impending diabetes with distinct HLA-DQ interactions.
Mbunwe E, Van der Auwera BJ, Weets I, Van Crombrugge P, Crenier L, Coeckelberghs M, Seret N, Decochez K, Vandemeulebroucke E, Gillard P, Keymeulen B, van Schravendijk C, Wenzlau JM, Hutton JC, Pipeleers DG, Gorus FK; Belgian Diabetes Registry. Mbunwe E, et al. Among authors: van der auwera bj. Diabetologia. 2013 Sep;56(9):1964-70. doi: 10.1007/s00125-013-2951-8. Epub 2013 May 28. Diabetologia. 2013. PMID: 23712485 Free PMC article.
Seasonality in clinical onset of type 1 diabetes in belgian patients above the age of 10 is restricted to HLA-DQ2/DQ8-negative males, which explains the male to female excess in incidence.
Weets I, Kaufman L, Van der Auwera B, Crenier L, Rooman RP, De Block C, Casteels K, Weber E, Coeckelberghs M, Laron Z, Pipeleers DG, Gorus FK; Belgian Diabetes Registry. Weets I, et al. Diabetologia. 2004 Apr;47(4):614-21. doi: 10.1007/s00125-004-1369-8. Diabetologia. 2004. PMID: 15298337
Hyperglycaemic clamp test for diabetes risk assessment in IA-2-antibody-positive relatives of type 1 diabetic patients.
Vandemeulebroucke E, Keymeulen B, Decochez K, Weets I, De Block C, Féry F, Van de Velde U, Vermeulen I, De Pauw P, Mathieu C, Pipeleers DG, Gorus FK; Belgian Diabetes Registry. Vandemeulebroucke E, et al. Diabetologia. 2010 Jan;53(1):36-44. doi: 10.1007/s00125-009-1569-3. Epub 2009 Nov 7. Diabetologia. 2010. PMID: 19898832 Free article.
63 results