Lee C - Search Results

1

Property-based optimization of hydroxamate-based γ-lactam HDAC inhibitors to improve their metabolic stability and pharmacokinetic profiles.

Choi E, Lee C, Cho M, Seo JJ, Yang JS, Oh SJ, Lee K, Park SK, Kim HM, Kwon HJ, Han G. Choi E, et al. Among authors: lee k, lee c. J Med Chem. 2012 Dec 13;55(23):10766-70. doi: 10.1021/jm3009376. Epub 2012 Dec 4. J Med Chem. 2012. PMID: 23163332

2

A novel delta-lactam-based histone deacetylase inhibitor, KBH-A42, induces cell cycle arrest and apoptosis in colon cancer cells.

Kang MR, Kang JS, Han SB, Kim JH, Kim DM, Lee K, Lee CW, Lee KH, Lee CH, Han G, Kang JS, Kim HM, Park SK. Kang MR, et al. Biochem Pharmacol. 2009 Sep 1;78(5):486-94. doi: 10.1016/j.bcp.2009.05.010. Epub 2009 May 13. Biochem Pharmacol. 2009. PMID: 19445901

3

Structure and property based design, synthesis and biological evaluation of γ-lactam based HDAC inhibitors.

Choi E, Lee C, Park JE, Seo JJ, Cho M, Kang JS, Kim HM, Park SK, Lee K, Han G. Choi E, et al. Among authors: lee k, lee c. Bioorg Med Chem Lett. 2011 Feb 15;21(4):1218-21. doi: 10.1016/j.bmcl.2010.12.079. Epub 2010 Dec 21. Bioorg Med Chem Lett. 2011. PMID: 21256006

4

Structure and property based design, synthesis and biological evaluation of γ-lactam based HDAC inhibitors: part II.

Lee C, Choi E, Cho M, Lee B, Oh SJ, Park SK, Lee K, Kim HM, Han G. Lee C, et al. Among authors: lee k, lee b. Bioorg Med Chem Lett. 2012 Jun 15;22(12):4189-92. doi: 10.1016/j.bmcl.2012.04.045. Epub 2012 Apr 21. Bioorg Med Chem Lett. 2012. PMID: 22578459

5

Discovery of pyridone-based histone deacetylase inhibitors: approaches for metabolic stability.

Cho M, Choi E, Yang JS, Lee C, Seo JJ, Kim BS, Oh SJ, Kim HM, Lee K, Park SK, Kwon HJ, Han G. Cho M, et al. Among authors: lee k, lee c. ChemMedChem. 2013 Feb;8(2):272-9. doi: 10.1002/cmdc.201200529. Epub 2013 Jan 4. ChemMedChem. 2013. PMID: 23292995

6

Discovery of thienopyrimidine-based FLT3 inhibitors from the structural modification of known IKKβ inhibitors.

Park CH, Lee C, Yang JS, Joe BY, Chun K, Kim H, Kim HY, Kang JS, Lee JI, Kim MH, Han G. Park CH, et al. Among authors: lee ji, lee c. Bioorg Med Chem Lett. 2014 Jun 15;24(12):2655-60. doi: 10.1016/j.bmcl.2014.04.058. Epub 2014 Apr 24. Bioorg Med Chem Lett. 2014. PMID: 24813730

7

Synthesis and biological evaluation of novel thieno[2,3-d]pyrimidine-based FLT3 inhibitors as anti-leukemic agents.

Yang JS, Park CH, Lee C, Kim H, Oh C, Choi Y, Kang JS, Yun J, Jeong JH, Kim MH, Han G. Yang JS, et al. Among authors: lee c. Eur J Med Chem. 2014 Oct 6;85:399-407. doi: 10.1016/j.ejmech.2014.08.001. Epub 2014 Aug 1. Eur J Med Chem. 2014. PMID: 25108079

8

Discovery of Orally Available Runt-Related Transcription Factor 3 (RUNX3) Modulators for Anticancer Chemotherapy by Epigenetic Activation and Protein Stabilization.

Yang JS, Lee C, Cho M, Kim H, Kim JH, Choi S, Oh SJ, Kang JS, Jeong JH, Kim HJ, Han G. Yang JS, et al. Among authors: lee c. J Med Chem. 2015 Apr 23;58(8):3512-21. doi: 10.1021/acs.jmedchem.5b00062. Epub 2015 Apr 9. J Med Chem. 2015. PMID: 25811792

9

Identification of a thienopyrimidine derivatives target by a kinome and chemical biology approach.

Lee C, Yang JS, Han G. Lee C, et al. Arch Pharm Res. 2015 Sep;38(9):1575-81. doi: 10.1007/s12272-015-0634-3. Epub 2015 Jul 18. Arch Pharm Res. 2015. PMID: 26186885 Review.

10

Structural modifications at the 6-position of thieno[2,3-d]pyrimidines and their effects on potency at FLT3 for treatment of acute myeloid leukemia.

Kim H, Lee C, Yang JS, Choi S, Park CH, Kang JS, Oh SJ, Yun J, Kim MH, Han G. Kim H, et al. Among authors: lee c. Eur J Med Chem. 2016 Sep 14;120:74-85. doi: 10.1016/j.ejmech.2016.05.022. Epub 2016 May 9. Eur J Med Chem. 2016. PMID: 27187860

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