De Simone A - Search Results

1

Amyloid β-peptide 25-35 self-assembly and its inhibition: a model undecapeptide system to gain atomistic and secondary structure details of the Alzheimer's disease process and treatment.

Naldi M, Fiori J, Pistolozzi M, Drake AF, Bertucci C, Wu R, Mlynarczyk K, Filipek S, De Simone A, Andrisano V. Naldi M, et al. Among authors: de simone a. ACS Chem Neurosci. 2012 Nov 21;3(11):952-62. doi: 10.1021/cn3000982. Epub 2012 Sep 4. ACS Chem Neurosci. 2012. PMID: 23173074 Free PMC article.

2

Structural characterization of p53 isoforms due to the polymorphism at codon 72 by mass spectrometry and circular dichroism.

Naldi M, Pistolozzi M, Bertucci C, De Simone A, Altilia S, Pierini M, Franceschi C, Salvioli S, Andrisano V. Naldi M, et al. Among authors: de simone a. J Pharm Biomed Anal. 2010 Oct 10;53(2):200-6. doi: 10.1016/j.jpba.2010.03.038. Epub 2010 Apr 2. J Pharm Biomed Anal. 2010. PMID: 20427142

3

Circular dichroism in drug discovery and development: an abridged review.

Bertucci C, Pistolozzi M, De Simone A. Bertucci C, et al. Among authors: de simone a. Anal Bioanal Chem. 2010 Sep;398(1):155-66. doi: 10.1007/s00216-010-3959-2. Epub 2010 Jul 25. Anal Bioanal Chem. 2010. PMID: 20658284 Review.

4

Beta-secretase as a target for Alzheimer's disease drug discovery: an overview of in vitro methods for characterization of inhibitors.

Mancini F, De Simone A, Andrisano V. Mancini F, et al. Among authors: de simone a. Anal Bioanal Chem. 2011 Jun;400(7):1979-96. doi: 10.1007/s00216-011-4963-x. Epub 2011 Apr 20. Anal Bioanal Chem. 2011. PMID: 21503735 Review.

5

Structural characterization of recombinant therapeutic proteins by circular dichroism.

Bertucci C, Pistolozzi M, De Simone A. Bertucci C, et al. Among authors: de simone a. Curr Pharm Biotechnol. 2011 Oct;12(10):1508-16. doi: 10.2174/138920111798357276. Curr Pharm Biotechnol. 2011. PMID: 21542799 Review.

6

Reversible human serum albumin binding of lipocrine: a circular dichroism study.

Bertucci C, De Simone A, Pistolozzi M, Rosini M. Bertucci C, et al. Among authors: de simone a. Chirality. 2011 Oct;23(9):827-32. doi: 10.1002/chir.21006. Epub 2011 Aug 25. Chirality. 2011. PMID: 21919078

7

A small chemical library of 2-aminoimidazole derivatives as BACE-1 inhibitors: Structure-based design, synthesis, and biological evaluation.

Chiriano G, De Simone A, Mancini F, Perez DI, Cavalli A, Bolognesi ML, Legname G, Martinez A, Andrisano V, Carloni P, Roberti M. Chiriano G, et al. Among authors: de simone a. Eur J Med Chem. 2012 Feb;48:206-13. doi: 10.1016/j.ejmech.2011.12.016. Epub 2011 Dec 16. Eur J Med Chem. 2012. PMID: 22209418

8

Human recombinant beta-secretase immobilized enzyme reactor for fast hits' selection and characterization from a virtual screening library.

De Simone A, Mancini F, Cosconati S, Marinelli L, La Pietra V, Novellino E, Andrisano V. De Simone A, et al. J Pharm Biomed Anal. 2013 Jan 25;73:131-4. doi: 10.1016/j.jpba.2012.03.006. Epub 2012 Mar 29. J Pharm Biomed Anal. 2013. PMID: 22502908

9

Surface plasmon resonance, fluorescence, and circular dichroism studies for the characterization of the binding of BACE-1 inhibitors.

De Simone A, Mancini F, Real Fernàndez F, Rovero P, Bertucci C, Andrisano V. De Simone A, et al. Anal Bioanal Chem. 2013 Jan;405(2-3):827-35. doi: 10.1007/s00216-012-6312-0. Epub 2012 Aug 29. Anal Bioanal Chem. 2013. PMID: 22926128

10

Protein flexibility in virtual screening: the BACE-1 case study.

Cosconati S, Marinelli L, Di Leva FS, La Pietra V, De Simone A, Mancini F, Andrisano V, Novellino E, Goodsell DS, Olson AJ. Cosconati S, et al. Among authors: de simone a. J Chem Inf Model. 2012 Oct 22;52(10):2697-704. doi: 10.1021/ci300390h. Epub 2012 Oct 8. J Chem Inf Model. 2012. PMID: 23005250 Free PMC article.

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