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In vitro digestion testing of lipid-based delivery systems: calcium ions combine with fatty acids liberated from triglyceride rich lipid solutions to form soaps and reduce the solubilization capacity of colloidal digestion products.
Devraj R, Williams HD, Warren DB, Mullertz A, Porter CJ, Pouton CW. Devraj R, et al. Among authors: williams hd. Int J Pharm. 2013 Jan 30;441(1-2):323-33. doi: 10.1016/j.ijpharm.2012.11.024. Epub 2012 Nov 23. Int J Pharm. 2013. PMID: 23178598
Toward the establishment of standardized in vitro tests for lipid-based formulations, part 1: method parameterization and comparison of in vitro digestion profiles across a range of representative formulations.
Williams HD, Sassene P, Kleberg K, Bakala-N'Goma JC, Calderone M, Jannin V, Igonin A, Partheil A, Marchaud D, Jule E, Vertommen J, Maio M, Blundell R, Benameur H, Carrière F, Müllertz A, Porter CJ, Pouton CW. Williams HD, et al. J Pharm Sci. 2012 Sep;101(9):3360-80. doi: 10.1002/jps.23205. Epub 2012 May 29. J Pharm Sci. 2012. PMID: 22644939
Toward the establishment of standardized in vitro tests for lipid-based formulations. 2. The effect of bile salt concentration and drug loading on the performance of type I, II, IIIA, IIIB, and IV formulations during in vitro digestion.
Williams HD, Anby MU, Sassene P, Kleberg K, Bakala-N'Goma JC, Calderone M, Jannin V, Igonin A, Partheil A, Marchaud D, Jule E, Vertommen J, Maio M, Blundell R, Benameur H, Carrière F, Müllertz A, Pouton CW, Porter CJ. Williams HD, et al. Mol Pharm. 2012 Nov 5;9(11):3286-300. doi: 10.1021/mp300331z. Epub 2012 Oct 22. Mol Pharm. 2012. PMID: 23030411
Toward the establishment of standardized in vitro tests for lipid-based formulations, part 3: understanding supersaturation versus precipitation potential during the in vitro digestion of type I, II, IIIA, IIIB and IV lipid-based formulations.
Williams HD, Sassene P, Kleberg K, Calderone M, Igonin A, Jule E, Vertommen J, Blundell R, Benameur H, Müllertz A, Pouton CW, Porter CJ; LFCS Consortium. Williams HD, et al. Pharm Res. 2013 Dec;30(12):3059-76. doi: 10.1007/s11095-013-1038-z. Epub 2013 May 10. Pharm Res. 2013. PMID: 23661145
Recent advances in lipid-based formulation technology.
Porter CJ, Williams HD, Trevaskis NL. Porter CJ, et al. Among authors: williams hd. Pharm Res. 2013 Dec;30(12):2971-5. doi: 10.1007/s11095-013-1229-7. Epub 2013 Oct 26. Pharm Res. 2013. PMID: 24158727 No abstract available.
120 results