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Discovery of salermide-related sirtuin inhibitors: binding mode studies and antiproliferative effects in cancer cells including cancer stem cells.
Rotili D, Tarantino D, Nebbioso A, Paolini C, Huidobro C, Lara E, Mellini P, Lenoci A, Pezzi R, Botta G, Lahtela-Kakkonen M, Poso A, Steinkühler C, Gallinari P, De Maria R, Fraga M, Esteller M, Altucci L, Mai A. Rotili D, et al. Among authors: lara e. J Med Chem. 2012 Dec 27;55(24):10937-47. doi: 10.1021/jm3011614. Epub 2012 Dec 12. J Med Chem. 2012. PMID: 23189967
Identification of tri- and tetracyclic pyrimidinediones as sirtuin inhibitors.
Rotili D, Tarantino D, Carafa V, Lara E, Meade S, Botta G, Nebbioso A, Schemies J, Jung M, Kazantsev AG, Esteller M, Fraga MF, Altucci L, Mai A. Rotili D, et al. Among authors: lara e. ChemMedChem. 2010 May 3;5(5):674-7. doi: 10.1002/cmdc.201000030. ChemMedChem. 2010. PMID: 20391556 No abstract available.
Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect.
Lara E, Mai A, Calvanese V, Altucci L, Lopez-Nieva P, Martinez-Chantar ML, Varela-Rey M, Rotili D, Nebbioso A, Ropero S, Montoya G, Oyarzabal J, Velasco S, Serrano M, Witt M, Villar-Garea A, Imhof A, Mato JM, Esteller M, Fraga MF. Lara E, et al. Oncogene. 2009 Feb 12;28(6):781-91. doi: 10.1038/onc.2008.436. Epub 2008 Dec 8. Oncogene. 2009. PMID: 19060927
Sirtuin 1 regulation of developmental genes during differentiation of stem cells.
Calvanese V, Lara E, Suárez-Alvarez B, Abu Dawud R, Vázquez-Chantada M, Martínez-Chantar ML, Embade N, López-Nieva P, Horrillo A, Hmadcha A, Soria B, Piazzolla D, Herranz D, Serrano M, Mato JM, Andrews PW, López-Larrea C, Esteller M, Fraga MF. Calvanese V, et al. Among authors: lara e. Proc Natl Acad Sci U S A. 2010 Aug 3;107(31):13736-41. doi: 10.1073/pnas.1001399107. Epub 2010 Jul 14. Proc Natl Acad Sci U S A. 2010. PMID: 20631301 Free PMC article.
Cancer genes hypermethylated in human embryonic stem cells.
Calvanese V, Horrillo A, Hmadcha A, Suarez-Alvarez B, Fernandez AF, Lara E, Casado S, Menendez P, Bueno C, Garcia-Castro J, Rubio R, Lapunzina P, Alaminos M, Borghese L, Terstegge S, Harrison NJ, Moore HD, Brüstle O, Lopez-Larrea C, Andrews PW, Soria B, Esteller M, Fraga MF. Calvanese V, et al. Among authors: lara e. PLoS One. 2008 Sep 29;3(9):e3294. doi: 10.1371/journal.pone.0003294. PLoS One. 2008. PMID: 18820729 Free PMC article.
Epigenetic code and self-identity.
Calvanese V, Lara E, Fraga MF. Calvanese V, et al. Among authors: lara e. Adv Exp Med Biol. 2012;738:236-55. doi: 10.1007/978-1-4614-1680-7_14. Adv Exp Med Biol. 2012. PMID: 22399383 Review.
The role of epigenetics in aging and age-related diseases.
Calvanese V, Lara E, Kahn A, Fraga MF. Calvanese V, et al. Among authors: lara e. Ageing Res Rev. 2009 Oct;8(4):268-76. doi: 10.1016/j.arr.2009.03.004. Epub 2009 Apr 1. Ageing Res Rev. 2009. PMID: 19716530 Review.
Genome-wide analysis of DNA methylation differences in muscle and fat from monozygotic twins discordant for type 2 diabetes.
Ribel-Madsen R, Fraga MF, Jacobsen S, Bork-Jensen J, Lara E, Calvanese V, Fernandez AF, Friedrichsen M, Vind BF, Højlund K, Beck-Nielsen H, Esteller M, Vaag A, Poulsen P. Ribel-Madsen R, et al. Among authors: lara e. PLoS One. 2012;7(12):e51302. doi: 10.1371/journal.pone.0051302. Epub 2012 Dec 10. PLoS One. 2012. PMID: 23251491 Free PMC article.
338 results