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CDX2-driven leukemogenesis involves KLF4 repression and deregulated PPARγ signaling.
Faber K, Bullinger L, Ragu C, Garding A, Mertens D, Miller C, Martin D, Walcher D, Döhner K, Döhner H, Claus R, Plass C, Sykes SM, Lane SW, Scholl C, Fröhling S. Faber K, et al. Among authors: miller c. J Clin Invest. 2013 Jan;123(1):299-314. doi: 10.1172/JCI64745. Epub 2012 Dec 3. J Clin Invest. 2013. PMID: 23202735 Free PMC article.
Micro-ribonucleic acid-155 is a direct target of Meis1, but not a driver in acute myeloid leukemia.
Schneider E, Staffas A, Röhner L, Malmberg ED, Ashouri A, Krowiorz K, Pochert N, Miller C, Wei SY, Arabanian L, Buske C, Döhner H, Bullinger L, Fogelstrand L, Heuser M, Döhner K, Xiang P, Ruschmann J, Petriv OI, Heravi-Moussavi A, Hansen CL, Hirst M, Humphries RK, Rouhi A, Palmqvist L, Kuchenbauer F. Schneider E, et al. Among authors: miller c. Haematologica. 2018 Feb;103(2):246-255. doi: 10.3324/haematol.2017.177485. Epub 2017 Dec 7. Haematologica. 2018. PMID: 29217774 Free PMC article.
MicroRNA-708 is a novel regulator of the Hoxa9 program in myeloid cells.
Schneider E, Pochert N, Ruess C, MacPhee L, Escano L, Miller C, Krowiorz K, Delsing Malmberg E, Heravi-Moussavi A, Lorzadeh A, Ashouri A, Grasedieck S, Sperb N, Kumar Kopparapu P, Iben S, Staffas A, Xiang P, Rösler R, Kanduri M, Larsson E, Fogelstrand L, Döhner H, Döhner K, Wiese S, Hirst M, Keith Humphries R, Palmqvist L, Kuchenbauer F, Rouhi A. Schneider E, et al. Among authors: miller c. Leukemia. 2020 May;34(5):1253-1265. doi: 10.1038/s41375-019-0651-1. Epub 2019 Nov 25. Leukemia. 2020. PMID: 31768018
MiR-139-5p is a potent tumor suppressor in adult acute myeloid leukemia.
Krowiorz K, Ruschmann J, Lai C, Ngom M, Maetzig T, Martins V, Scheffold A, Schneider E, Pochert N, Miller C, Palmqvist L, Staffas A, Mulaw M, Bohl SR, Buske C, Heuser M, Kraus J, O'Neill K, Hansen CL, Petriv OI, Kestler H, Döhner H, Bullinger L, Döhner K, Humphries RK, Rouhi A, Kuchenbauer F. Krowiorz K, et al. Among authors: miller c. Blood Cancer J. 2016 Dec 9;6(12):e508. doi: 10.1038/bcj.2016.110. Blood Cancer J. 2016. PMID: 27935579 Free PMC article. No abstract available.
FDA Approval Summary: Tovorafenib for Relapsed or Refractory BRAF-altered Pediatric Low-Grade Glioma.
Singh S, Bradford D, Chatterjee S, Li X, Aungst SL, Skinner AM, Miller CP, Kim-McOlash S, Fourie Zirkelbach J, Xiong Y, Bi Y, Wang YH, Yang Y, Sun J, Kraft J, Charlab R, Shord SS, Tang S, Scepura B, Bulatao I, Udoka O, Saber H, Rahman NA, Pazdur R, Singh H, Donoghue M, Drezner N. Singh S, et al. Among authors: miller cp. Clin Cancer Res. 2025 Jan 14. doi: 10.1158/1078-0432.CCR-24-3439. Online ahead of print. Clin Cancer Res. 2025. PMID: 39808502
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