Totzke F - Search Results

1

Assessing the target differentiation potential of imidazole-based protein kinase inhibitors.

Dimova D, Iyer P, Vogt M, Totzke F, Kubbutat MH, Schächtele C, Laufer S, Bajorath J. Dimova D, et al. Among authors: totzke f. J Med Chem. 2012 Dec 27;55(24):11067-71. doi: 10.1021/jm3014508. Epub 2012 Dec 11. J Med Chem. 2012. PMID: 23210446

2

1-Aryl-4,6-dihydropyrazolo[4,3-d][1]benzazepin-5(1H)-ones: a new class of antiproliferative agents with selectivity for human leukemia and breast cancer cell lines.

Kohfeld S, Jones PG, Totzke F, Schächtele C, Kubbutat MH, Kunick C. Kohfeld S, et al. Among authors: totzke f. Eur J Med Chem. 2007 Nov-Dec;42(11-12):1317-24. doi: 10.1016/j.ejmech.2007.02.007. Epub 2007 Mar 1. Eur J Med Chem. 2007. PMID: 17448574

3

Identification of 2-anilino-9-methoxy-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-ones as dual PLK1/VEGF-R2 kinase inhibitor chemotypes by structure-based lead generation.

Egert-Schmidt AM, Dreher J, Dunkel U, Kohfeld S, Preu L, Weber H, Ehlert JE, Mutschler B, Totzke F, Schächtele C, Kubbutat MH, Baumann K, Kunick C. Egert-Schmidt AM, et al. Among authors: totzke f. J Med Chem. 2010 Mar 25;53(6):2433-42. doi: 10.1021/jm901388c. J Med Chem. 2010. PMID: 20170163

4

Dual IGF-1R/SRC inhibitors based on a N'-aroyl-2-(1H-indol-3-yl)-2-oxoacetohydrazide structure.

Schmidt S, Preu L, Lemcke T, Totzke F, Schächtele C, Kubbutat MH, Kunick C. Schmidt S, et al. Among authors: totzke f. Eur J Med Chem. 2011 Jul;46(7):2759-69. doi: 10.1016/j.ejmech.2011.03.065. Epub 2011 Apr 6. Eur J Med Chem. 2011. PMID: 21524503

5

Tri- and tetrasubstituted pyrazole derivates: regioisomerism switches activity from p38MAP kinase to important cancer kinases.

Abu Thaher B, Arnsmann M, Totzke F, Ehlert JE, Kubbutat MH, Schächtele C, Zimmermann MO, Koch P, Boeckler FM, Laufer SA. Abu Thaher B, et al. Among authors: totzke f. J Med Chem. 2012 Jan 26;55(2):961-5. doi: 10.1021/jm201391u. Epub 2012 Jan 17. J Med Chem. 2012. PMID: 22185282

6

2-Anilino-4-(benzimidazol-2-yl)pyrimidines--a multikinase inhibitor scaffold with antiproliferative activity toward cancer cell lines.

Determann R, Dreher J, Baumann K, Preu L, Jones PG, Totzke F, Schächtele C, Kubbutat MH, Kunick C. Determann R, et al. Among authors: totzke f. Eur J Med Chem. 2012 Jul;53:254-63. doi: 10.1016/j.ejmech.2012.04.007. Epub 2012 Apr 14. Eur J Med Chem. 2012. PMID: 22560627

7

Novel 2-chloro-4-anilino-quinazoline derivatives as EGFR and VEGFR-2 dual inhibitors.

Barbosa ML, Lima LM, Tesch R, Sant'Anna CM, Totzke F, Kubbutat MH, Schächtele C, Laufer SA, Barreiro EJ. Barbosa ML, et al. Among authors: totzke f. Eur J Med Chem. 2014 Jan;71:1-14. doi: 10.1016/j.ejmech.2013.10.058. Epub 2013 Oct 31. Eur J Med Chem. 2014. PMID: 24269511

8

Development of first lead structures for phosphoinositide 3-kinase-C2γ inhibitors.

Freitag A, Prajwal P, Shymanets A, Harteneck C, Nürnberg B, Schächtele C, Kubbutat M, Totzke F, Laufer SA. Freitag A, et al. Among authors: totzke f. J Med Chem. 2015 Jan 8;58(1):212-21. doi: 10.1021/jm5006034. Epub 2014 Jul 14. J Med Chem. 2015. PMID: 24983663

9

Novel CDK inhibition profiles of structurally varied 1-aza-9-oxafluorenes.

Voigt B, Meijer L, Lozach O, Schächtele C, Totzke F, Hilgeroth A. Voigt B, et al. Among authors: totzke f. Bioorg Med Chem Lett. 2005 Feb 1;15(3):823-5. doi: 10.1016/j.bmcl.2004.10.091. Bioorg Med Chem Lett. 2005. PMID: 15664865

10

Structure-aided optimization of kinase inhibitors derived from alsterpaullone.

Kunick C, Zeng Z, Gussio R, Zaharevitz D, Leost M, Totzke F, Schächtele C, Kubbutat MH, Meijer L, Lemcke T. Kunick C, et al. Among authors: totzke f. Chembiochem. 2005 Mar;6(3):541-9. doi: 10.1002/cbic.200400099. Chembiochem. 2005. PMID: 15696597

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