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Aminophylline, administered at usual doses for rodents in pharmacological studies, induces hippocampal neuronal cell injury under low tidal volume hypoxic conditions in guinea-pigs.
Somekawa-Kondo T, Yamaguchi K, Ishitsuka Y, Ito S, Tanaka K, Irikura M, Moriuchi H, Takahama K, Ando Y, Yamazaki T, Irie T. Somekawa-Kondo T, et al. J Pharm Pharmacol. 2013 Jan;65(1):102-14. doi: 10.1111/j.2042-7158.2012.01566.x. Epub 2012 Jul 29. J Pharm Pharmacol. 2013. PMID: 23215693