Zalubovskis R - Search Results

1

Sulfocoumarins (1,2-benzoxathiine-2,2-dioxides): a class of potent and isoform-selective inhibitors of tumor-associated carbonic anhydrases.

Tars K, Vullo D, Kazaks A, Leitans J, Lends A, Grandane A, Zalubovskis R, Scozzafava A, Supuran CT. Tars K, et al. Among authors: zalubovskis r. J Med Chem. 2013 Jan 10;56(1):293-300. doi: 10.1021/jm301625s. Epub 2012 Dec 27. J Med Chem. 2013. PMID: 23241068

2

5-Substituted-(1,2,3-triazol-4-yl)thiophene-2-sulfonamides strongly inhibit human carbonic anhydrases I, II, IX and XII: solution and X-ray crystallographic studies.

Leitans J, Sprudza A, Tanc M, Vozny I, Zalubovskis R, Tars K, Supuran CT. Leitans J, et al. Among authors: zalubovskis r. Bioorg Med Chem. 2013 Sep 1;21(17):5130-8. doi: 10.1016/j.bmc.2013.06.041. Epub 2013 Jun 27. Bioorg Med Chem. 2013. PMID: 23859774

3

Synthesis of 6-tetrazolyl-substituted sulfocoumarins acting as highly potent and selective inhibitors of the tumor-associated carbonic anhydrase isoforms IX and XII.

Grandane A, Tanc M, Zalubovskis R, Supuran CT. Grandane A, et al. Among authors: zalubovskis r. Bioorg Med Chem. 2014 Mar 1;22(5):1522-8. doi: 10.1016/j.bmc.2014.01.043. Epub 2014 Feb 1. Bioorg Med Chem. 2014. PMID: 24513186

4

6-Triazolyl-substituted sulfocoumarins are potent, selective inhibitors of the tumor-associated carbonic anhydrases IX and XII.

Grandane A, Tanc M, Zalubovskis R, Supuran CT. Grandane A, et al. Among authors: zalubovskis r. Bioorg Med Chem Lett. 2014 Mar 1;24(5):1256-60. doi: 10.1016/j.bmcl.2014.01.076. Epub 2014 Feb 2. Bioorg Med Chem Lett. 2014. PMID: 24518190

5

5-membered cyclic hydroxamic acids as HDAC inhibitors.

Mutule I, Borovika D, Rozenberga E, Romanchikova N, Zalubovskis R, Shestakova I, Trapencieris P. Mutule I, et al. Among authors: zalubovskis r. J Enzyme Inhib Med Chem. 2015 Apr;30(2):216-23. doi: 10.3109/14756366.2014.912214. Epub 2014 Jun 18. J Enzyme Inhib Med Chem. 2015. PMID: 24939099 Free article.

6

Hydrophobic substituents of the phenylmethylsulfamide moiety can be used for the development of new selective carbonic anhydrase inhibitors.

De Simone G, Pizika G, Monti SM, Di Fiore A, Ivanova J, Vozny I, Trapencieris P, Zalubovskis R, Supuran CT, Alterio V. De Simone G, et al. Among authors: zalubovskis r. Biomed Res Int. 2014;2014:523210. doi: 10.1155/2014/523210. Epub 2014 Sep 2. Biomed Res Int. 2014. PMID: 25258712 Free PMC article.

7

X-ray crystallographic and kinetic investigations of 6-sulfamoyl-saccharin as a carbonic anhydrase inhibitor.

Alterio V, Tanc M, Ivanova J, Zalubovskis R, Vozny I, Monti SM, Di Fiore A, De Simone G, Supuran CT. Alterio V, et al. Among authors: zalubovskis r. Org Biomol Chem. 2015 Apr 7;13(13):4064-9. doi: 10.1039/c4ob02648a. Org Biomol Chem. 2015. PMID: 25733161

8

Synthesis of 6-aryl-substituted sulfocoumarins and investigation of their carbonic anhydrase inhibitory action.

Grandane A, Tanc M, Žalubovskis R, Supuran CT. Grandane A, et al. Among authors: zalubovskis r. Bioorg Med Chem. 2015 Apr 1;23(7):1430-6. doi: 10.1016/j.bmc.2015.02.023. Epub 2015 Feb 21. Bioorg Med Chem. 2015. PMID: 25753329

9

X-ray crystallography-promoted drug design of carbonic anhydrase inhibitors.

Ivanova J, Leitans J, Tanc M, Kazaks A, Zalubovskis R, Supuran CT, Tars K. Ivanova J, et al. Among authors: zalubovskis r. Chem Commun (Camb). 2015 Apr 28;51(33):7108-11. doi: 10.1039/c5cc01854d. Chem Commun (Camb). 2015. PMID: 25813715

10

6-Substituted sulfocoumarins are selective carbonic anhdydrase IX and XII inhibitors with significant cytotoxicity against colorectal cancer cells.

Grandane A, Tanc M, Di Cesare Mannelli L, Carta F, Ghelardini C, Žalubovskis R, Supuran CT. Grandane A, et al. Among authors: zalubovskis r. J Med Chem. 2015 May 14;58(9):3975-83. doi: 10.1021/acs.jmedchem.5b00523. Epub 2015 Apr 23. J Med Chem. 2015. PMID: 25875209

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