Walkinshaw G - Search Results

1

Pharmacologic stabilization of HIF-1α increases hematopoietic stem cell quiescence in vivo and accelerates blood recovery after severe irradiation.

Forristal CE, Winkler IG, Nowlan B, Barbier V, Walkinshaw G, Levesque JP. Forristal CE, et al. Among authors: walkinshaw g. Blood. 2013 Jan 31;121(5):759-69. doi: 10.1182/blood-2012-02-408419. Epub 2012 Dec 14. Blood. 2013. PMID: 23243286 Free article.

2

HIF prolyl hydroxylase inhibitor FG-4497 enhances mouse hematopoietic stem cell mobilization via VEGFR2/KDR.

Bisht K, Brunck ME, Matsumoto T, McGirr C, Nowlan B, Fleming W, Keech T, Magor G, Perkins AC, Davies J, Walkinshaw G, Flippin L, Winkler IG, Levesque JP. Bisht K, et al. Among authors: walkinshaw g. Blood Adv. 2019 Feb 12;3(3):406-418. doi: 10.1182/bloodadvances.2018017566. Blood Adv. 2019. PMID: 30733301 Free PMC article.

3

HIF-1α is required for hematopoietic stem cell mobilization and 4-prolyl hydroxylase inhibitors enhance mobilization by stabilizing HIF-1α.

Forristal CE, Nowlan B, Jacobsen RN, Barbier V, Walkinshaw G, Walkley CR, Winkler IG, Levesque JP. Forristal CE, et al. Among authors: walkinshaw g. Leukemia. 2015 Jun;29(6):1366-78. doi: 10.1038/leu.2015.8. Epub 2015 Jan 12. Leukemia. 2015. PMID: 25578474 Free PMC article.

4

HIF-1α-stabilizing agent FG-4497 rescues human CD34⁺ cell mobilization in response to G-CSF in immunodeficient mice.

Nowlan B, Futrega K, Brunck ME, Walkinshaw G, Flippin LE, Doran MR, Levesque JP. Nowlan B, et al. Among authors: walkinshaw g. Exp Hematol. 2017 Aug;52:50-55.e6. doi: 10.1016/j.exphem.2017.05.004. Epub 2017 May 17. Exp Hematol. 2017. PMID: 28527810 Free article.

5

Transmembrane prolyl 4-hydroxylase is a fourth prolyl 4-hydroxylase regulating EPO production and erythropoiesis.

Laitala A, Aro E, Walkinshaw G, Mäki JM, Rossi M, Heikkilä M, Savolainen ER, Arend M, Kivirikko KI, Koivunen P, Myllyharju J. Laitala A, et al. Among authors: walkinshaw g. Blood. 2012 Oct 18;120(16):3336-44. doi: 10.1182/blood-2012-07-441824. Epub 2012 Sep 5. Blood. 2012. PMID: 22955912 Free article.

6

Short-term effects of pharmacologic HIF stabilization on vasoactive and cytotrophic factors in developing mouse brain.

Schneider C, Krischke G, Keller S, Walkinshaw G, Arend M, Rascher W, Gassmann M, Trollmann R. Schneider C, et al. Among authors: walkinshaw g. Brain Res. 2009 Jul 14;1280:43-51. doi: 10.1016/j.brainres.2009.05.023. Epub 2009 May 18. Brain Res. 2009. PMID: 19450570

7

Non-hypoxic stabilization of hypoxia-inducible factor alpha (HIF-alpha): relevance in neural progenitor/stem cells.

Milosevic J, Adler I, Manaenko A, Schwarz SC, Walkinshaw G, Arend M, Flippin LA, Storch A, Schwarz J. Milosevic J, et al. Among authors: walkinshaw g. Neurotox Res. 2009 May;15(4):367-80. doi: 10.1007/s12640-009-9043-z. Epub 2009 Mar 20. Neurotox Res. 2009. PMID: 19384570

8

Pharmacologic stabilization of hypoxia-inducible transcription factors protects developing mouse brain from hypoxia-induced apoptotic cell death.

Trollmann R, Richter M, Jung S, Walkinshaw G, Brackmann F. Trollmann R, et al. Among authors: walkinshaw g. Neuroscience. 2014 Oct 10;278:327-42. doi: 10.1016/j.neuroscience.2014.08.019. Epub 2014 Aug 24. Neuroscience. 2014. PMID: 25162122

9

Contribution of HIF-P4H isoenzyme inhibition to metabolism indicates major beneficial effects being conveyed by HIF-P4H-2 antagonism.

Tapio J, Halmetoja R, Dimova EY, Mäki JM, Laitala A, Walkinshaw G, Myllyharju J, Serpi R, Koivunen P. Tapio J, et al. Among authors: walkinshaw g. J Biol Chem. 2022 Aug;298(8):102222. doi: 10.1016/j.jbc.2022.102222. Epub 2022 Jul 1. J Biol Chem. 2022. PMID: 35787374 Free PMC article.

10

Hypoxia-Inducible Factor Prolyl 4-Hydroxylase-2 Inhibition Protects Against Development of Atherosclerosis.

Rahtu-Korpela L, Määttä J, Dimova EY, Hörkkö S, Gylling H, Walkinshaw G, Hakkola J, Kivirikko KI, Myllyharju J, Serpi R, Koivunen P. Rahtu-Korpela L, et al. Among authors: walkinshaw g. Arterioscler Thromb Vasc Biol. 2016 Apr;36(4):608-17. doi: 10.1161/ATVBAHA.115.307136. Epub 2016 Feb 4. Arterioscler Thromb Vasc Biol. 2016. PMID: 26848160

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