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Spliceosome integrity is defective in the motor neuron diseases ALS and SMA.
Tsuiji H, Iguchi Y, Furuya A, Kataoka A, Hatsuta H, Atsuta N, Tanaka F, Hashizume Y, Akatsu H, Murayama S, Sobue G, Yamanaka K. Tsuiji H, et al. Among authors: yamanaka k. EMBO Mol Med. 2013 Feb;5(2):221-34. doi: 10.1002/emmm.201202303. Epub 2013 Jan 25. EMBO Mol Med. 2013. PMID: 23255347 Free PMC article.
Loss of TDP-43 causes age-dependent progressive motor neuron degeneration.
Iguchi Y, Katsuno M, Niwa J, Takagi S, Ishigaki S, Ikenaka K, Kawai K, Watanabe H, Yamanaka K, Takahashi R, Misawa H, Sasaki S, Tanaka F, Sobue G. Iguchi Y, et al. Among authors: yamanaka k. Brain. 2013 May;136(Pt 5):1371-82. doi: 10.1093/brain/awt029. Epub 2013 Feb 28. Brain. 2013. PMID: 23449777
TDP-43 accelerates age-dependent degeneration of interneurons.
Tsuiji H, Inoue I, Takeuchi M, Furuya A, Yamakage Y, Watanabe S, Koike M, Hattori M, Yamanaka K. Tsuiji H, et al. Among authors: yamanaka k. Sci Rep. 2017 Nov 2;7(1):14972. doi: 10.1038/s41598-017-14966-w. Sci Rep. 2017. PMID: 29097807 Free PMC article.
1,750 results