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Carnosic acid suppresses the production of amyloid-β 1-42 by inducing the metalloprotease gene TACE/ADAM17 in SH-SY5Y human neuroblastoma cells.
Meng P, Yoshida H, Matsumiya T, Imaizumi T, Tanji K, Xing F, Hayakari R, Dempoya J, Tatsuta T, Aizawa-Yashiro T, Mimura J, Kosaka K, Itoh K, Satoh K. Meng P, et al. Among authors: kosaka k. Neurosci Res. 2013 Feb;75(2):94-102. doi: 10.1016/j.neures.2012.11.007. Epub 2012 Dec 17. Neurosci Res. 2013. PMID: 23257508
Carnosic acid protects neuronal HT22 Cells through activation of the antioxidant-responsive element in free carboxylic acid- and catechol hydroxyl moieties-dependent manners.
Satoh T, Izumi M, Inukai Y, Tsutsumi Y, Nakayama N, Kosaka K, Shimojo Y, Kitajima C, Itoh K, Yokoi T, Shirasawa T. Satoh T, et al. Among authors: kosaka k. Neurosci Lett. 2008 Apr 4;434(3):260-5. doi: 10.1016/j.neulet.2008.01.079. Epub 2008 Feb 13. Neurosci Lett. 2008. PMID: 18329808
In a previous study, we found that carnosic acid (CA) protected cortical neurons by activating the Keap1/Nrf2 pathway, which activation was initiated by S-alkylation of the critical cysteine thiol of the Keap1 protein by the "electrophilic"quinone-type of CA [T. Satoh, K. …
In a previous study, we found that carnosic acid (CA) protected cortical neurons by activating the Keap1/Nrf2 pathway, which activation was …
Carnosic acid, a catechol-type electrophilic compound, protects neurons both in vitro and in vivo through activation of the Keap1/Nrf2 pathway via S-alkylation of targeted cysteines on Keap1.
Satoh T, Kosaka K, Itoh K, Kobayashi A, Yamamoto M, Shimojo Y, Kitajima C, Cui J, Kamins J, Okamoto S, Izumi M, Shirasawa T, Lipton SA. Satoh T, et al. Among authors: kosaka k. J Neurochem. 2008 Feb;104(4):1116-31. doi: 10.1111/j.1471-4159.2007.05039.x. Epub 2007 Nov 6. J Neurochem. 2008. PMID: 17995931 Free PMC article.
1,090 results