Jerome GM - Search Results

1

Discovery and SAR of PF-4693627, a potent, selective and orally bioavailable mPGES-1 inhibitor for the potential treatment of inflammation.

Arhancet GB, Walker DP, Metz S, Fobian YM, Heasley SE, Carter JS, Springer JR, Jones DE, Hayes MJ, Shaffer AF, Jerome GM, Baratta MT, Zweifel B, Moore WM, Masferrer JL, Vazquez ML. Arhancet GB, et al. Among authors: jerome gm. Bioorg Med Chem Lett. 2013 Feb 15;23(4):1114-9. doi: 10.1016/j.bmcl.2012.11.109. Epub 2012 Dec 6. Bioorg Med Chem Lett. 2013. PMID: 23260349

2

Synthesis and biological evaluation of substituted benzoxazoles as inhibitors of mPGES-1: use of a conformation-based hypothesis to facilitate compound design.

Walker DP, Arhancet GB, Lu HF, Heasley SE, Metz S, Kablaoui NM, Franco FM, Hanau CE, Scholten JA, Springer JR, Fobian YM, Carter JS, Xing L, Yang S, Shaffer AF, Jerome GM, Baratta MT, Moore WM, Vazquez ML. Walker DP, et al. Among authors: jerome gm. Bioorg Med Chem Lett. 2013 Feb 15;23(4):1120-6. doi: 10.1016/j.bmcl.2012.11.107. Epub 2012 Dec 12. Bioorg Med Chem Lett. 2013. PMID: 23298810

3

3-Hydroxy-4-methyl-5-pentyl-2-iminopyrrolidine: a potent and highly selective inducible nitric oxide synthase inhibitor.

Tsymbalov S, Hagen TJ, Moore WM, Jerome GM, Connor JR, Manning PT, Pitzele BS, Hallinan EA. Tsymbalov S, et al. Among authors: jerome gm. Bioorg Med Chem Lett. 2002 Nov 18;12(22):3337-9. doi: 10.1016/s0960-894x(02)00686-8. Bioorg Med Chem Lett. 2002. PMID: 12392746

4

Selective heterocyclic amidine inhibitors of human inducible nitric oxide synthase.

Moormann AE, Metz S, Toth MV, Moore WM, Jerome G, Kornmeier C, Manning P, Hansen DW Jr, Pitzele BS, Webber RK. Moormann AE, et al. Bioorg Med Chem Lett. 2001 Oct 8;11(19):2651-3. doi: 10.1016/s0960-894x(01)00523-6. Bioorg Med Chem Lett. 2001. PMID: 11551770

5

Synthesis and biological characterization of L-N(6)-(1-iminoethyl)lysine 5-tetrazole-amide, a prodrug of a selective iNOS inhibitor.

Hallinan EA, Tsymbalov S, Dorn CR, Pitzele BS, Hansen DW Jr, Moore WM, Jerome GM, Connor JR, Branson LF, Widomski DL, Zhang Y, Currie MG, Manning PT. Hallinan EA, et al. Among authors: jerome gm. J Med Chem. 2002 Apr 11;45(8):1686-9. doi: 10.1021/jm010420e. J Med Chem. 2002. PMID: 11931623

6

Inhibitors of human nitric oxide synthase isoforms with the carbamidine moiety as a common structural element.

Moore WM, Webber RK, Fok KF, Jerome GM, Kornmeier CM, Tjoeng FS, Currie MG. Moore WM, et al. Among authors: jerome gm. Bioorg Med Chem. 1996 Sep;4(9):1559-64. doi: 10.1016/0968-0896(96)00148-4. Bioorg Med Chem. 1996. PMID: 8894112

7

Substituted 2-iminopiperidines as inhibitors of human nitric oxide synthase isoforms.

Webber RK, Metz S, Moore WM, Connor JR, Currie MG, Fok KF, Hagen TJ, Hansen DW Jr, Jerome GM, Manning PT, Pitzele BS, Toth MV, Trivedi M, Zupec ME, Tjoeng FS. Webber RK, et al. Among authors: jerome gm. J Med Chem. 1998 Jan 1;41(1):96-101. doi: 10.1021/jm9705059. J Med Chem. 1998. PMID: 9438025

8

2-Iminohomopiperidinium salts as selective inhibitors of inducible nitric oxide synthase (iNOS).

Hansen DW Jr, Peterson KB, Trivedi M, Kramer SW, Webber RK, Tjoeng FS, Moore WM, Jerome GM, Kornmeier CM, Manning PT, Connor JR, Misko TP, Currie MG, Pitzele BS. Hansen DW Jr, et al. Among authors: jerome gm. J Med Chem. 1998 Apr 23;41(9):1361-6. doi: 10.1021/jm9704715. J Med Chem. 1998. PMID: 9554868

9

2-Iminopyrrolidines as potent and selective inhibitors of human inducible nitric oxide synthase.

Hagen TJ, Bergmanis AA, Kramer SW, Fok KF, Schmelzer AE, Pitzele BS, Swenton L, Jerome GM, Kornmeier CM, Moore WM, Branson LF, Connor JR, Manning PT, Currie MG, Hallinan EA. Hagen TJ, et al. Among authors: jerome gm. J Med Chem. 1998 Sep 10;41(19):3675-83. doi: 10.1021/jm970840x. J Med Chem. 1998. PMID: 9733492

10

5-Fluorinated L-lysine analogues as selective induced nitric oxide synthase inhibitors.

Hallinan EA, Hagen TJ, Bergmanis A, Moore WM, Jerome GM, Spangler DP, Stevens AM, Shieh HS, Manning PT, Pitzele BS. Hallinan EA, et al. Among authors: jerome gm. J Med Chem. 2004 Feb 12;47(4):900-6. doi: 10.1021/jm030348f. J Med Chem. 2004. PMID: 14761191

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