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Induced expression of cytochrome P450 1A and NAD(P)H:quinone oxidoreductase determined at mRNA, protein, and enzyme activity levels in rats exposed to the carcinogenic azo dye 1-phenylazo-2-naphthol (Sudan I).
Stiborová M, Dračínská H, Martínek V, Svášková D, Hodek P, Milichovský J, Hejduková Ž, Brotánek J, Schmeiser HH, Frei E. Stiborová M, et al. Among authors: schmeiser hh. Chem Res Toxicol. 2013 Feb 18;26(2):290-9. doi: 10.1021/tx3004533. Epub 2013 Jan 15. Chem Res Toxicol. 2013. PMID: 23289503
The environmental pollutant and carcinogen 3-nitrobenzanthrone and its human metabolite 3-aminobenzanthrone are potent inducers of rat hepatic cytochromes P450 1A1 and -1A2 and NAD(P)H:quinone oxidoreductase.
Stiborová M, Dracínská H, Hájková J, Kaderábková P, Frei E, Schmeiser HH, Soucek P, Phillips DH, Arlt VM. Stiborová M, et al. Among authors: schmeiser hh. Drug Metab Dispos. 2006 Aug;34(8):1398-405. doi: 10.1124/dmd.106.009373. Epub 2006 May 19. Drug Metab Dispos. 2006. PMID: 16714372
The environmental pollutant and carcinogen 3-nitrobenzanthrone induces cytochrome P450 1A1 and NAD(P)H:quinone oxidoreductase in rat lung and kidney, thereby enhancing its own genotoxicity.
Stiborová M, Dracínská H, Mizerovská J, Frei E, Schmeiser HH, Hudecek J, Hodek P, Phillips DH, Arlt VM. Stiborová M, et al. Among authors: schmeiser hh. Toxicology. 2008 May 2;247(1):11-22. doi: 10.1016/j.tox.2008.01.018. Epub 2008 Feb 6. Toxicology. 2008. PMID: 18329153
Redox cycling in the metabolism of the environmental pollutant and suspected human carcinogen o-anisidine by rat and rabbit hepatic microsomes.
Naiman K, Dracínská H, Martínková M, Sulc M, Dracínský M, Kejíková L, Hodek P, Hudecek J, Liberda J, Schmeiser HH, Frei E, Stiborová M. Naiman K, et al. Among authors: schmeiser hh. Chem Res Toxicol. 2008 Aug;21(8):1610-21. doi: 10.1021/tx8001127. Epub 2008 Jul 15. Chem Res Toxicol. 2008. PMID: 18624415
179 results