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Levels of soluble apolipoprotein E/amyloid-β (Aβ) complex are reduced and oligomeric Aβ increased with APOE4 and Alzheimer disease in a transgenic mouse model and human samples.
Tai LM, Bilousova T, Jungbauer L, Roeske SK, Youmans KL, Yu C, Poon WW, Cornwell LB, Miller CA, Vinters HV, Van Eldik LJ, Fardo DW, Estus S, Bu G, Gylys KH, Ladu MJ. Tai LM, et al. Among authors: fardo dw. J Biol Chem. 2013 Feb 22;288(8):5914-26. doi: 10.1074/jbc.M112.442103. Epub 2013 Jan 4. J Biol Chem. 2013. PMID: 23293020 Free PMC article.
Genetic expression changes and pathologic findings associated with hyperhomocysteinemia in human autopsy brain tissue.
Weekman EM, Winder Z, Rogers CB, Abner EL, Sudduth TL, Patel E, Dugan AJ, Fister SX, Wasek B, Nelson PT, Jicha GA, Bottiglieri T, Fardo DW, Wilcock DM. Weekman EM, et al. Among authors: fardo dw. Alzheimers Dement (N Y). 2022 Dec 8;8(1):e12368. doi: 10.1002/trc2.12368. eCollection 2022. Alzheimers Dement (N Y). 2022. PMID: 36514441 Free PMC article.
Genetics ignite focus on microglial inflammation in Alzheimer's disease.
Malik M, Parikh I, Vasquez JB, Smith C, Tai L, Bu G, LaDu MJ, Fardo DW, Rebeck GW, Estus S. Malik M, et al. Among authors: fardo dw. Mol Neurodegener. 2015 Oct 5;10:52. doi: 10.1186/s13024-015-0048-1. Mol Neurodegener. 2015. PMID: 26438529 Free PMC article. Review.
Assessment of the genetic variance of late-onset Alzheimer's disease.
Ridge PG, Hoyt KB, Boehme K, Mukherjee S, Crane PK, Haines JL, Mayeux R, Farrer LA, Pericak-Vance MA, Schellenberg GD, Kauwe JSK; Alzheimer's Disease Genetics Consortium (ADGC). Ridge PG, et al. Neurobiol Aging. 2016 May;41:200.e13-200.e20. doi: 10.1016/j.neurobiolaging.2016.02.024. Epub 2016 Mar 3. Neurobiol Aging. 2016. PMID: 27036079 Free PMC article.
"New Old Pathologies": AD, PART, and Cerebral Age-Related TDP-43 With Sclerosis (CARTS).
Nelson PT, Trojanowski JQ, Abner EL, Al-Janabi OM, Jicha GA, Schmitt FA, Smith CD, Fardo DW, Wang WX, Kryscio RJ, Neltner JH, Kukull WA, Cykowski MD, Van Eldik LJ, Ighodaro ET. Nelson PT, et al. Among authors: fardo dw. J Neuropathol Exp Neurol. 2016 Jun;75(6):482-98. doi: 10.1093/jnen/nlw033. Epub 2016 May 21. J Neuropathol Exp Neurol. 2016. PMID: 27209644 Free PMC article. Review.
173 results