Tikhonova IG - Search Results

1

Old drug, new target: ellipticines selectively inhibit RNA polymerase I transcription.

Andrews WJ, Panova T, Normand C, Gadal O, Tikhonova IG, Panov KI. Andrews WJ, et al. Among authors: tikhonova ig. J Biol Chem. 2013 Feb 15;288(7):4567-82. doi: 10.1074/jbc.M112.411611. Epub 2013 Jan 4. J Biol Chem. 2013. PMID: 23293027 Free PMC article.

2

Unexpected Activity of a Novel Kunitz-type Inhibitor: INHIBITION OF CYSTEINE PROTEASES BUT NOT SERINE PROTEASES.

Smith D, Tikhonova IG, Jewhurst HL, Drysdale OC, Dvořák J, Robinson MW, Cwiklinski K, Dalton JP. Smith D, et al. Among authors: tikhonova ig. J Biol Chem. 2016 Sep 9;291(37):19220-34. doi: 10.1074/jbc.M116.724344. Epub 2016 Jul 15. J Biol Chem. 2016. PMID: 27422822 Free PMC article.

3

The cytoplasmic tail of L-selectin interacts with the adaptor-protein complex AP-1 subunit μ1A via a novel basic binding motif.

Dib K, Tikhonova IG, Ivetic A, Schu P. Dib K, et al. Among authors: tikhonova ig. J Biol Chem. 2017 Apr 21;292(16):6703-6714. doi: 10.1074/jbc.M116.768598. Epub 2017 Feb 24. J Biol Chem. 2017. PMID: 28235798 Free PMC article.

4

Probing the mid-gorge of cholinesterases with spacer-modified bivalent quinazolinimines leads to highly potent and selective butyrylcholinesterase inhibitors.

Chen X, Tikhonova IG, Decker M. Chen X, et al. Among authors: tikhonova ig. Bioorg Med Chem. 2011 Feb 1;19(3):1222-35. doi: 10.1016/j.bmc.2010.12.034. Epub 2010 Dec 21. Bioorg Med Chem. 2011. PMID: 21232964

5

Extracellular ionic locks determine variation in constitutive activity and ligand potency between species orthologs of the free fatty acid receptors FFA2 and FFA3.

Hudson BD, Tikhonova IG, Pandey SK, Ulven T, Milligan G. Hudson BD, et al. Among authors: tikhonova ig. J Biol Chem. 2012 Nov 30;287(49):41195-209. doi: 10.1074/jbc.M112.396259. Epub 2012 Oct 12. J Biol Chem. 2012. PMID: 23066016 Free PMC article.

6

Defining the molecular basis for the first potent and selective orthosteric agonists of the FFA2 free fatty acid receptor.

Hudson BD, Due-Hansen ME, Christiansen E, Hansen AM, Mackenzie AE, Murdoch H, Pandey SK, Ward RJ, Marquez R, Tikhonova IG, Ulven T, Milligan G. Hudson BD, et al. Among authors: tikhonova ig. J Biol Chem. 2013 Jun 14;288(24):17296-312. doi: 10.1074/jbc.M113.455337. Epub 2013 Apr 15. J Biol Chem. 2013. PMID: 23589301 Free PMC article.

7

Solid phase synthesis of Smac/DIABLO-derived peptides using a 'Safety-Catch' resin: identification of potent XIAP BIR3 antagonists.

Elsawy MA, Martin L, Tikhonova IG, Walker B. Elsawy MA, et al. Among authors: tikhonova ig. Bioorg Med Chem. 2013 Sep 1;21(17):5004-11. doi: 10.1016/j.bmc.2013.06.055. Epub 2013 Jul 2. Bioorg Med Chem. 2013. PMID: 23886811

8

Free fatty acid receptor 1 (GPR40) agonists containing spirocyclic periphery inspired by LY2881835.

Krasavin M, Lukin A, Bagnyukova D, Zhurilo N, Zahanich I, Zozulya S, Ihalainen J, Forsberg MM, Lehtonen M, Rautio J, Moore D, Tikhonova IG. Krasavin M, et al. Among authors: tikhonova ig. Bioorg Med Chem. 2016 Nov 1;24(21):5481-5494. doi: 10.1016/j.bmc.2016.09.004. Epub 2016 Sep 3. Bioorg Med Chem. 2016. PMID: 27647366

9

Selective phosphorylation of threonine residues defines GPR84-arrestin interactions of biased ligands.

Marsango S, Ward RJ, Jenkins L, Butcher AJ, Al Mahmud Z, Dwomoh L, Nagel F, Schulz S, Tikhonova IG, Tobin AB, Milligan G. Marsango S, et al. Among authors: tikhonova ig. J Biol Chem. 2022 May;298(5):101932. doi: 10.1016/j.jbc.2022.101932. Epub 2022 Apr 12. J Biol Chem. 2022. PMID: 35427647 Free PMC article.

10

Comparison of dynamics of extracellular accesses to the β(1) and β(2) adrenoceptors binding sites uncovers the potential of kinetic basis of antagonist selectivity.

Selvam B, Wereszczynski J, Tikhonova IG. Selvam B, et al. Among authors: tikhonova ig. Chem Biol Drug Des. 2012 Aug;80(2):215-26. doi: 10.1111/j.1747-0285.2012.01390.x. Epub 2012 May 2. Chem Biol Drug Des. 2012. PMID: 22530954 Free PMC article.

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