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A G protein-biased ligand at the μ-opioid receptor is potently analgesic with reduced gastrointestinal and respiratory dysfunction compared with morphine.
DeWire SM, Yamashita DS, Rominger DH, Liu G, Cowan CL, Graczyk TM, Chen XT, Pitis PM, Gotchev D, Yuan C, Koblish M, Lark MW, Violin JD. DeWire SM, et al. Among authors: liu g. J Pharmacol Exp Ther. 2013 Mar;344(3):708-17. doi: 10.1124/jpet.112.201616. Epub 2013 Jan 8. J Pharmacol Exp Ther. 2013. PMID: 23300227
Structure-activity relationships and discovery of a G protein biased μ opioid receptor ligand, [(3-methoxythiophen-2-yl)methyl]({2-[(9R)-9-(pyridin-2-yl)-6-oxaspiro-[4.5]decan-9-yl]ethyl})amine (TRV130), for the treatment of acute severe pain.
Chen XT, Pitis P, Liu G, Yuan C, Gotchev D, Cowan CL, Rominger DH, Koblish M, Dewire SM, Crombie AL, Violin JD, Yamashita DS. Chen XT, et al. Among authors: liu g. J Med Chem. 2013 Oct 24;56(20):8019-31. doi: 10.1021/jm4010829. Epub 2013 Oct 14. J Med Chem. 2013. PMID: 24063433
Copper homeostasis; A rapier between mycobacteria and macrophages.
Hu D, Yang Z, Zhang JA, Liu G, Pi J, Xu J, Wang Y, Zhao Y. Hu D, et al. Among authors: liu g. FASEB Bioadv. 2024 Dec 25;7(1):e1484. doi: 10.1096/fba.2024-00166. eCollection 2025 Jan. FASEB Bioadv. 2024. PMID: 39781425 Free PMC article. Review.
Enhanced immunogenicity of a BoHV-1 gG-/tk- vaccine.
Zhang S, Liu G, Wang C, Guo A, Chen Y. Zhang S, et al. Among authors: liu g. Vaccine. 2025 Jan 7;47:126704. doi: 10.1016/j.vaccine.2025.126704. Online ahead of print. Vaccine. 2025. PMID: 39778477
35,444 results
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