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Braf(V600E) cooperates with Pten loss to induce metastatic melanoma.
Dankort D, Curley DP, Cartlidge RA, Nelson B, Karnezis AN, Damsky WE Jr, You MJ, DePinho RA, McMahon M, Bosenberg M. Dankort D, et al. Among authors: mcmahon m. Nat Genet. 2009 May;41(5):544-52. doi: 10.1038/ng.356. Epub 2009 Mar 12. Nat Genet. 2009. PMID: 19282848 Free PMC article.
An ultraviolet-radiation-independent pathway to melanoma carcinogenesis in the red hair/fair skin background.
Mitra D, Luo X, Morgan A, Wang J, Hoang MP, Lo J, Guerrero CR, Lennerz JK, Mihm MC, Wargo JA, Robinson KC, Devi SP, Vanover JC, D'Orazio JA, McMahon M, Bosenberg MW, Haigis KM, Haber DA, Wang Y, Fisher DE. Mitra D, et al. Among authors: mcmahon m. Nature. 2012 Nov 15;491(7424):449-53. doi: 10.1038/nature11624. Epub 2012 Oct 31. Nature. 2012. PMID: 23123854 Free PMC article.
Cancer biology: Enzyme meets a surprise target.
Deuker MM, McMahon M. Deuker MM, et al. Among authors: mcmahon m. Nature. 2014 Jun 12;510(7504):225-6. doi: 10.1038/nature13343. Epub 2014 May 21. Nature. 2014. PMID: 24847879 Free PMC article. No abstract available.
The Hippo effector YAP promotes resistance to RAF- and MEK-targeted cancer therapies.
Lin L, Sabnis AJ, Chan E, Olivas V, Cade L, Pazarentzos E, Asthana S, Neel D, Yan JJ, Lu X, Pham L, Wang MM, Karachaliou N, Cao MG, Manzano JL, Ramirez JL, Torres JM, Buttitta F, Rudin CM, Collisson EA, Algazi A, Robinson E, Osman I, Muñoz-Couselo E, Cortes J, Frederick DT, Cooper ZA, McMahon M, Marchetti A, Rosell R, Flaherty KT, Wargo JA, Bivona TG. Lin L, et al. Among authors: mcmahon m. Nat Genet. 2015 Mar;47(3):250-6. doi: 10.1038/ng.3218. Epub 2015 Feb 9. Nat Genet. 2015. PMID: 25665005 Free PMC article.
Transposon mutagenesis identifies genetic drivers of Braf(V600E) melanoma.
Mann MB, Black MA, Jones DJ, Ward JM, Yew CC, Newberg JY, Dupuy AJ, Rust AG, Bosenberg MW, McMahon M, Print CG, Copeland NG, Jenkins NA. Mann MB, et al. Among authors: mcmahon m. Nat Genet. 2015 May;47(5):486-95. doi: 10.1038/ng.3275. Epub 2015 Apr 13. Nat Genet. 2015. PMID: 25848750 Free PMC article.
Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers.
Kinsey CG, Camolotto SA, Boespflug AM, Guillen KP, Foth M, Truong A, Schuman SS, Shea JE, Seipp MT, Yap JT, Burrell LD, Lum DH, Whisenant JR, Gilcrease GW 3rd, Cavalieri CC, Rehbein KM, Cutler SL, Affolter KE, Welm AL, Welm BE, Scaife CL, Snyder EL, McMahon M. Kinsey CG, et al. Among authors: mcmahon m. Nat Med. 2019 Apr;25(4):620-627. doi: 10.1038/s41591-019-0367-9. Epub 2019 Mar 4. Nat Med. 2019. PMID: 30833748 Free PMC article.
Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis.
Thayer SP, di Magliano MP, Heiser PW, Nielsen CM, Roberts DJ, Lauwers GY, Qi YP, Gysin S, Fernández-del Castillo C, Yajnik V, Antoniu B, McMahon M, Warshaw AL, Hebrok M. Thayer SP, et al. Among authors: mcmahon m. Nature. 2003 Oct 23;425(6960):851-6. doi: 10.1038/nature02009. Epub 2003 Sep 14. Nature. 2003. PMID: 14520413 Free PMC article.
1,511 results