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A multivalent approach towards linked dual-pharmacology prostaglandin F receptor agonist/carbonic anhydrase-II inhibitors for the treatment of glaucoma.
Long DD, Frieman B, Hegde SS, Hill CM, Jiang L, Kintz S, Marquess DG, Purkey H, Shaw JP, Steinfeld T, Wilson MS, Wrench K. Long DD, et al. Among authors: shaw jp. Bioorg Med Chem Lett. 2013 Feb 15;23(4):939-43. doi: 10.1016/j.bmcl.2012.12.058. Epub 2012 Dec 22. Bioorg Med Chem Lett. 2013. PMID: 23317571
Discovery, oral pharmacokinetics and in vivo efficacy of a highly selective 5-HT4 receptor agonist: clinical compound TD-2749.
Long DD, Armstrong SR, Beattie DT, Choi SK, Fatheree PR, Gendron RA, Goldblum AA, Humphrey PP, Marquess DG, Shaw JP, Smith JA, Derek Turner S, Vickery RG. Long DD, et al. Among authors: shaw jp. Bioorg Med Chem Lett. 2012 Jul 15;22(14):4849-53. doi: 10.1016/j.bmcl.2012.05.034. Epub 2012 May 15. Bioorg Med Chem Lett. 2012. PMID: 22683222
Discovery, oral pharmacokinetics and in vivo efficacy of velusetrag, a highly selective 5-HT(4) receptor agonist that has achieved proof-of-concept in patients with chronic idiopathic constipation.
Long DD, Armstrong SR, Beattie DT, Choi SK, Fatheree PR, Gendron RA, Genov D, Goldblum AA, Humphrey PP, Jiang L, Marquess DG, Shaw JP, Smith JA, Turner SD, Vickery RG. Long DD, et al. Among authors: shaw jp. Bioorg Med Chem Lett. 2012 Oct 1;22(19):6048-52. doi: 10.1016/j.bmcl.2012.08.051. Epub 2012 Aug 21. Bioorg Med Chem Lett. 2012. PMID: 22959244
Pharmacodynamics of TD-1792, a novel glycopeptide-cephalosporin heterodimer antibiotic used against Gram-positive bacteria, in a neutropenic murine thigh model.
Hegde SS, Okusanya OO, Skinner R, Shaw JP, Obedencio G, Ambrose PG, Blais J, Bhavnani SM. Hegde SS, et al. Among authors: shaw jp. Antimicrob Agents Chemother. 2012 Mar;56(3):1578-83. doi: 10.1128/AAC.05382-11. Epub 2011 Dec 12. Antimicrob Agents Chemother. 2012. PMID: 22155835 Free PMC article.
Vancomycin disulfide derivatives as antibacterial agents.
Mu Y, Nodwell M, Pace JL, Shaw JP, Judice JK. Mu Y, et al. Among authors: shaw jp. Bioorg Med Chem Lett. 2004 Feb 9;14(3):735-8. doi: 10.1016/j.bmcl.2003.11.040. Bioorg Med Chem Lett. 2004. PMID: 14741279
144 results