Denny WA - Search Results

1

The fate of N1'-methanesulphonyl-N4'-(9-acridinyl)-3'-methoxy-2',5'-cyclohexadiene- 1',4'-diimine (m-AQDI), the primary oxidative metabolite of amsacrine, in transformed Chinese hamster fibroblasts.

Robbie MA, Palmer BD, Denny WA, Wilson WR. Robbie MA, et al. Among authors: denny wa. Biochem Pharmacol. 1990 May 1;39(9):1411-21. doi: 10.1016/0006-2952(90)90422-h. Biochem Pharmacol. 1990. PMID: 2334441

2

Mechanism of resistance of noncycling mammalian cells to 4'-(9-acridinylamino)methanesulfon-m-anisidide: comparison of uptake, metabolism, and DNA breakage in log- and plateau-phase Chinese hamster fibroblast cell cultures.

Robbie MA, Baguley BC, Denny WA, Gavin JB, Wilson WR. Robbie MA, et al. Among authors: denny wa. Cancer Res. 1988 Jan 15;48(2):310-9. Cancer Res. 1988. PMID: 2825971

3

Comparison of aromatic and tertiary amine N-oxides of acridine DNA intercalators as bioreductive drugs. Cytotoxicity, DNA binding, cellular uptake, and metabolism.

Siim BG, Hicks KO, Pullen SM, van Zijl PL, Denny WA, Wilson WR. Siim BG, et al. Among authors: denny wa. Biochem Pharmacol. 2000 Oct 1;60(7):969-78. doi: 10.1016/s0006-2952(00)00420-2. Biochem Pharmacol. 2000. PMID: 10974206

4

Effect of nitroreduction on the alkylating reactivity and cytotoxicity of the 2,4-dinitrobenzamide-5-aziridine CB 1954 and the corresponding nitrogen mustard SN 23862: distinct mechanisms of bioreductive activation.

Helsby NA, Wheeler SJ, Pruijn FB, Palmer BD, Yang S, Denny WA, Wilson WR. Helsby NA, et al. Among authors: denny wa. Chem Res Toxicol. 2003 Apr;16(4):469-78. doi: 10.1021/tx025662b. Chem Res Toxicol. 2003. PMID: 12703963

5

Synthesis and evaluation of nitroheterocyclic carbamate prodrugs for use with nitroreductase-mediated gene-directed enzyme prodrug therapy.

Hay MP, Anderson RF, Ferry DM, Wilson WR, Denny WA. Hay MP, et al. Among authors: denny wa. J Med Chem. 2003 Dec 4;46(25):5533-45. doi: 10.1021/jm030308b. J Med Chem. 2003. PMID: 14640560

6

Aziridinyldinitrobenzamides: synthesis and structure-activity relationships for activation by E. coli nitroreductase.

Helsby NA, Atwell GJ, Yang S, Palmer BD, Anderson RF, Pullen SM, Ferry DM, Hogg A, Wilson WR, Denny WA. Helsby NA, et al. Among authors: denny wa. J Med Chem. 2004 Jun 3;47(12):3295-307. doi: 10.1021/jm0498699. J Med Chem. 2004. PMID: 15163209

7

5-Nitro-4-(N,N-dimethylaminopropylamino)quinoline (5-nitraquine), a new DNA-affinic hypoxic cell radiosensitizer and bioreductive agent: comparison with nitracrine.

Wilson WR, Siim BG, Denny WA, van Zijl PL, Taylor ML, Chambers DM, Roberts PB. Wilson WR, et al. Among authors: denny wa. Radiat Res. 1992 Sep;131(3):257-65. Radiat Res. 1992. PMID: 1438685

8

Hypoxia-selective antitumor agents. 5. Synthesis of water-soluble nitroaniline mustards with selective cytotoxicity for hypoxic mammalian cells.

Palmer BD, Wilson WR, Cliffe S, Denny WA. Palmer BD, et al. Among authors: denny wa. J Med Chem. 1992 Aug 21;35(17):3214-22. doi: 10.1021/jm00095a018. J Med Chem. 1992. PMID: 1507207

9

Bis-bioreductive agents as hypoxia-selective cytotoxins: nitracrine N-oxide.

Wilson WR, Van Zijl P, Denny WA. Wilson WR, et al. Among authors: denny wa. Int J Radiat Oncol Biol Phys. 1992;22(4):693-6. doi: 10.1016/0360-3016(92)90505-c. Int J Radiat Oncol Biol Phys. 1992. PMID: 1544839

10

DNA-directed alkylating agents. 4. 4-anilinoquinoline-based minor groove directed aniline mustards.

Gravatt GL, Baguley BC, Wilson WR, Denny WA. Gravatt GL, et al. Among authors: denny wa. J Med Chem. 1991 May;34(5):1552-60. doi: 10.1021/jm00109a005. J Med Chem. 1991. PMID: 2033580

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