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Proteasomal degradation of herpes simplex virus capsids in macrophages releases DNA to the cytosol for recognition by DNA sensors.
Horan KA, Hansen K, Jakobsen MR, Holm CK, Søby S, Unterholzner L, Thompson M, West JA, Iversen MB, Rasmussen SB, Ellermann-Eriksen S, Kurt-Jones E, Landolfo S, Damania B, Melchjorsen J, Bowie AG, Fitzgerald KA, Paludan SR. Horan KA, et al. Among authors: holm ck. J Immunol. 2013 Mar 1;190(5):2311-9. doi: 10.4049/jimmunol.1202749. Epub 2013 Jan 23. J Immunol. 2013. PMID: 23345332 Free PMC article.
TLR3 deficiency renders astrocytes permissive to herpes simplex virus infection and facilitates establishment of CNS infection in mice.
Reinert LS, Harder L, Holm CK, Iversen MB, Horan KA, Dagnæs-Hansen F, Ulhøi BP, Holm TH, Mogensen TH, Owens T, Nyengaard JR, Thomsen AR, Paludan SR. Reinert LS, et al. Among authors: holm ck, holm th. J Clin Invest. 2012 Apr;122(4):1368-76. doi: 10.1172/JCI60893. Epub 2012 Mar 19. J Clin Invest. 2012. PMID: 22426207 Free PMC article.
Virus-cell fusion as a trigger of innate immunity dependent on the adaptor STING.
Holm CK, Jensen SB, Jakobsen MR, Cheshenko N, Horan KA, Moeller HB, Gonzalez-Dosal R, Rasmussen SB, Christensen MH, Yarovinsky TO, Rixon FJ, Herold BC, Fitzgerald KA, Paludan SR. Holm CK, et al. Nat Immunol. 2012 Jun 17;13(8):737-43. doi: 10.1038/ni.2350. Nat Immunol. 2012. PMID: 22706339 Free PMC article.
DNA recognition in immunity and disease.
Holm CK, Paludan SR, Fitzgerald KA. Holm CK, et al. Curr Opin Immunol. 2013 Feb;25(1):13-8. doi: 10.1016/j.coi.2012.12.006. Epub 2013 Jan 9. Curr Opin Immunol. 2013. PMID: 23313533 Free PMC article. Review.
T cells detect intracellular DNA but fail to induce type I IFN responses: implications for restriction of HIV replication.
Berg RK, Rahbek SH, Kofod-Olsen E, Holm CK, Melchjorsen J, Jensen DG, Hansen AL, Jørgensen LB, Ostergaard L, Tolstrup M, Larsen CS, Paludan SR, Jakobsen MR, Mogensen TH. Berg RK, et al. Among authors: holm ck. PLoS One. 2014 Jan 3;9(1):e84513. doi: 10.1371/journal.pone.0084513. eCollection 2014. PLoS One. 2014. PMID: 24404168 Free PMC article.
57 results