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Naphthoquinone derivatives exert their antitrypanosomal activity via a multi-target mechanism.
Pieretti S, Haanstra JR, Mazet M, Perozzo R, Bergamini C, Prati F, Fato R, Lenaz G, Capranico G, Brun R, Bakker BM, Michels PA, Scapozza L, Bolognesi ML, Cavalli A. Pieretti S, et al. Among authors: bakker bm. PLoS Negl Trop Dis. 2013;7(1):e2012. doi: 10.1371/journal.pntd.0002012. Epub 2013 Jan 17. PLoS Negl Trop Dis. 2013. PMID: 23350008 Free PMC article.
Compartmentation prevents a lethal turbo-explosion of glycolysis in trypanosomes.
Haanstra JR, van Tuijl A, Kessler P, Reijnders W, Michels PA, Westerhoff HV, Parsons M, Bakker BM. Haanstra JR, et al. Among authors: bakker bm. Proc Natl Acad Sci U S A. 2008 Nov 18;105(46):17718-23. doi: 10.1073/pnas.0806664105. Epub 2008 Nov 13. Proc Natl Acad Sci U S A. 2008. PMID: 19008351 Free PMC article.
Drug target identification through systems biology.
Haanstra JR, Bakker BM. Haanstra JR, et al. Among authors: bakker bm. Drug Discov Today Technol. 2015 Aug;15:17-22. doi: 10.1016/j.ddtec.2015.06.002. Epub 2015 Jul 17. Drug Discov Today Technol. 2015. PMID: 26464086 Review.
A domino effect in drug action: from metabolic assault towards parasite differentiation.
Haanstra JR, Kerkhoven EJ, van Tuijl A, Blits M, Wurst M, van Nuland R, Albert MA, Michels PA, Bouwman J, Clayton C, Westerhoff HV, Bakker BM. Haanstra JR, et al. Among authors: bakker bm. Mol Microbiol. 2011 Jan;79(1):94-108. doi: 10.1111/j.1365-2958.2010.07435.x. Epub 2010 Nov 5. Mol Microbiol. 2011. PMID: 21166896 Free article.
Targeting pathogen metabolism without collateral damage to the host.
Haanstra JR, Gerding A, Dolga AM, Sorgdrager FJH, Buist-Homan M, du Toit F, Faber KN, Holzhütter HG, Szöör B, Matthews KR, Snoep JL, Westerhoff HV, Bakker BM. Haanstra JR, et al. Among authors: bakker bm. Sci Rep. 2017 Jan 13;7:40406. doi: 10.1038/srep40406. Sci Rep. 2017. PMID: 28084422 Free PMC article.
The silicon trypanosome: a test case of iterative model extension in systems biology.
Achcar F, Fadda A, Haanstra JR, Kerkhoven EJ, Kim DH, Leroux AE, Papamarkou T, Rojas F, Bakker BM, Barrett MP, Clayton C, Girolami M, Krauth-Siegel RL, Matthews KR, Breitling R. Achcar F, et al. Among authors: bakker bm. Adv Microb Physiol. 2014;64:115-43. doi: 10.1016/B978-0-12-800143-1.00003-8. Adv Microb Physiol. 2014. PMID: 24797926 Free PMC article. Review.
142 results