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Page 1
Structural basis for pH-insensitive inhibition of immunoglobulin G recycling by an anti-neonatal Fc receptor antibody.
Kenniston JA, Taylor BM, Conley GP, Cosic J, Kopacz KJ, Lindberg AP, Comeau SR, Atkins K, Bullen J, TenHoor C, Adelman BA, Sexton DJ, Edwards TE, Nixon AE. Kenniston JA, et al. Among authors: conley gp. J Biol Chem. 2017 Oct 20;292(42):17449-17460. doi: 10.1074/jbc.M117.807396. Epub 2017 Sep 6. J Biol Chem. 2017. PMID: 28878017 Free PMC article.
Inhibition of plasma kallikrein by a highly specific active site blocking antibody.
Kenniston JA, Faucette RR, Martik D, Comeau SR, Lindberg AP, Kopacz KJ, Conley GP, Chen J, Viswanathan M, Kastrapeli N, Cosic J, Mason S, DiLeo M, Abendroth J, Kuzmic P, Ladner RC, Edwards TE, TenHoor C, Adelman BA, Nixon AE, Sexton DJ. Kenniston JA, et al. Among authors: conley gp. J Biol Chem. 2014 Aug 22;289(34):23596-608. doi: 10.1074/jbc.M114.569061. Epub 2014 Jun 26. J Biol Chem. 2014. PMID: 24970892 Free PMC article.
Novel peptide inhibitors of angiotensin-converting enzyme 2.
Huang L, Sexton DJ, Skogerson K, Devlin M, Smith R, Sanyal I, Parry T, Kent R, Enright J, Wu QL, Conley G, DeOliveira D, Morganelli L, Ducar M, Wescott CR, Ladner RC. Huang L, et al. J Biol Chem. 2003 May 2;278(18):15532-40. doi: 10.1074/jbc.M212934200. Epub 2003 Feb 26. J Biol Chem. 2003. PMID: 12606557 Free article.
A distinct strategy to generate high-affinity peptide binders to receptor tyrosine kinases.
Shrivastava A, von Wronski MA, Sato AK, Dransfield DT, Sexton D, Bogdan N, Pillai R, Nanjappan P, Song B, Marinelli E, DeOliveira D, Luneau C, Devlin M, Muruganandam A, Abujoub A, Connelly G, Wu QL, Conley G, Chang Q, Tweedle MF, Ladner RC, Swenson RE, Nunn AD. Shrivastava A, et al. Protein Eng Des Sel. 2005 Sep;18(9):417-24. doi: 10.1093/protein/gzi049. Epub 2005 Aug 8. Protein Eng Des Sel. 2005. PMID: 16087652
A human monoclonal antibody against insulin-like growth factor-II blocks the growth of human hepatocellular carcinoma cell lines in vitro and in vivo.
Dransfield DT, Cohen EH, Chang Q, Sparrow LG, Bentley JD, Dolezal O, Xiao X, Peat TS, Newman J, Pilling PA, Phan T, Priebe I, Brierley GV, Kastrapeli N, Kopacz K, Martik D, Wassaf D, Rank D, Conley G, Huang Y, Adams TE, Cosgrove L. Dransfield DT, et al. Mol Cancer Ther. 2010 Jun;9(6):1809-19. doi: 10.1158/1535-7163.MCT-09-1134. Epub 2010 Jun 1. Mol Cancer Ther. 2010. PMID: 20515953
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