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JNK activation and translocation to mitochondria mediates mitochondrial dysfunction and cell death induced by VDAC opening and sorafenib in hepatocarcinoma cells.
Heslop KA, Rovini A, Hunt EG, Fang D, Morris ME, Christie CF, Gooz MB, DeHart DN, Dang Y, Lemasters JJ, Maldonado EN. Heslop KA, et al. Among authors: rovini a. Biochem Pharmacol. 2020 Jan;171:113728. doi: 10.1016/j.bcp.2019.113728. Epub 2019 Nov 21. Biochem Pharmacol. 2020. PMID: 31759978 Free PMC article.
Statin-dependent modulation of mitochondrial metabolism in cancer cells is independent of cholesterol content.
Christie CF, Fang D, Hunt EG, Morris ME, Rovini A, Heslop KA, Beeson GC, Beeson CC, Maldonado EN. Christie CF, et al. Among authors: rovini a. FASEB J. 2019 Jul;33(7):8186-8201. doi: 10.1096/fj.201802723R. Epub 2019 Apr 5. FASEB J. 2019. PMID: 30951369 Free PMC article.
Statins, widely used to treat hypercholesterolemia, inhibit the 3-hydroxy-3-methylglutaryl-coenzyme A reductase, the rate-limiting enzyme of de novo cholesterol (Chol) synthesis. Statins have been also reported to slow tumor progression. ...F., Fang, D., Hunt, E. G., Morri …
Statins, widely used to treat hypercholesterolemia, inhibit the 3-hydroxy-3-methylglutaryl-coenzyme A reductase, the rate-limiting en …
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