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Design, synthesis, and SAR of N-((1-(4-(propylsulfonyl)piperazin-1-yl)cycloalkyl)methyl)benzamide inhibitors of glycine transporter-1.
Cioffi CL, Wolf MA, Guzzo PR, Sadalapure K, Parthasarathy V, Dethe D, Maeng JH, Carulli E, Loong DT, Fang X, Hu M, Gupta P, Chung M, Bai M, Moore N, Luche M, Khmelnitsky Y, Love PL, Watson MA, Mhyre AJ, Liu S. Cioffi CL, et al. Among authors: moore n. Bioorg Med Chem Lett. 2013 Mar 1;23(5):1257-61. doi: 10.1016/j.bmcl.2013.01.006. Epub 2013 Jan 11. Bioorg Med Chem Lett. 2013. PMID: 23380375
Synthesis and Biological Evaluation of N-((1-(4-(Sulfonyl)piperazin-1-yl)cycloalkyl)methyl)benzamide Inhibitors of Glycine Transporter-1.
Cioffi CL, Liu S, Wolf MA, Guzzo PR, Sadalapure K, Parthasarathy V, Loong DT, Maeng JH, Carulli E, Fang X, Karunakaran K, Matta L, Choo SH, Panduga S, Buckle RN, Davis RN, Sakwa SA, Gupta P, Sargent BJ, Moore NA, Luche MM, Carr GJ, Khmelnitsky YL, Ismail J, Chung M, Bai M, Leong WY, Sachdev N, Swaminathan S, Mhyre AJ. Cioffi CL, et al. Among authors: moore na. J Med Chem. 2016 Sep 22;59(18):8473-94. doi: 10.1021/acs.jmedchem.6b00914. Epub 2016 Sep 9. J Med Chem. 2016. PMID: 27559615 Free article.
CSTI-300 (SMP-100); a Novel 5-HT3 Receptor Partial Agonist with Potential to Treat Patients with Irritable Bowel Syndrome or Carcinoid Syndrome.
Roberts A, Grafton G, Powell AD, Brock K, Chen C, Xie D, Huang J, Liu S, Cooper AJ, Brady CA, Qureshi O, Stamataki Z, Manning DD, Moore NA, Sargent BJ, Guzzo PR, Barnes NM. Roberts A, et al. J Pharmacol Exp Ther. 2020 Apr;373(1):122-134. doi: 10.1124/jpet.119.261008. Epub 2020 Feb 26. J Pharmacol Exp Ther. 2020. PMID: 32102919
New central targets for the treatment of obesity.
Sargent BJ, Moore NA. Sargent BJ, et al. Br J Clin Pharmacol. 2009 Dec;68(6):852-60. doi: 10.1111/j.1365-2125.2009.03550.x. Br J Clin Pharmacol. 2009. PMID: 20002079 Free PMC article. Review.
Basic Science and Pathogenesis.
Moore NC, Song YE, Lynn A, Miskimen KL, Wang W, Laux RA, Fuzzell SL, Hochstetler SD, Caywood LJ, Clouse JE, Herington SD, Nittala MG, Sadda SR, Stambolian D, Lerner AJ, Vance JM, Cuccaro ML, Scott WK, Pericak-Vance MA, Haines JL. Moore NC, et al. Alzheimers Dement. 2024 Dec;20 Suppl 1:e089652. doi: 10.1002/alz.089652. Alzheimers Dement. 2024. PMID: 39751118
Basic Science and Pathogenesis.
Dorfsman DA, Prough MB, Gulyayev AV, Caywood LJ, Clouse JE, Herington SD, Slifer SH, Adams LD, Laux RA, Song YE, Lynn A, Fuzzell SL, Hochstetler SD, Miskimen KL, Main LR, Wang P, Liu Y, Moore NC, Ogrocki PK, Lerner AJ, Vance JM, Cuccaro ML, Pericak-Vance MA, Scott WK. Dorfsman DA, et al. Among authors: moore nc. Alzheimers Dement. 2024 Dec;20 Suppl 1:e090963. doi: 10.1002/alz.090963. Alzheimers Dement. 2024. PMID: 39750800
Basic Science and Pathogenesis.
Song YE, Laux RA, Fuzzell SL, Hochstetler SD, Miskimen KL, Lynn A, Wang W, Main LR, Wang P, Liu Y, Moore NC, Prough MB, Dorfsman DA, Caywood LJ, Clouse JE, Herington SD, Gulyayev AV, Slifer SH, Adams LD, Vance JM, Cuccaro ML, Ogrocki PK, Lerner AJ, Pericak-Vance MA, Scott WK, Bush WS, Haines JL. Song YE, et al. Among authors: moore nc. Alzheimers Dement. 2024 Dec;20 Suppl 1:e089681. doi: 10.1002/alz.089681. Alzheimers Dement. 2024. PMID: 39750726
1,597 results