Boettcher A - Search Results

1

In vivo imaging with fluorescent smart probes to assess treatment strategies for acute pancreatitis.

Agarwal A, Boettcher A, Kneuer R, Sari-Sarraf F, Donovan A, Woelcke J, Simic O, Brandl T, Krucker T. Agarwal A, et al. Among authors: boettcher a. PLoS One. 2013;8(2):e55959. doi: 10.1371/journal.pone.0055959. Epub 2013 Feb 11. PLoS One. 2013. PMID: 23409095 Free PMC article.

2

Fragment-based screening by biochemical assays: Systematic feasibility studies with trypsin and MMP12.

Boettcher A, Ruedisser S, Erbel P, Vinzenz D, Schiering N, Hassiepen U, Rigollier P, Mayr LM, Woelcke J. Boettcher A, et al. J Biomol Screen. 2010 Oct;15(9):1029-41. doi: 10.1177/1087057110380455. Epub 2010 Sep 20. J Biomol Screen. 2010. PMID: 20855559

3

Fluorescence Lifetime-Based Competitive Binding Assays for Measuring the Binding Potency of Protease Inhibitors In Vitro.

Boettcher A, Gradoux N, Lorthiois E, Brandl T, Orain D, Schiering N, Cumin F, Woelcke J, Hassiepen U. Boettcher A, et al. J Biomol Screen. 2014 Jul;19(6):870-7. doi: 10.1177/1087057114521295. Epub 2014 Jan 31. J Biomol Screen. 2014. PMID: 24487225

4

Readout technologies for highly miniaturized kinase assays applicable to high-throughput screening in a 1536-well format.

Klumpp M, Boettcher A, Becker D, Meder G, Blank J, Leder L, Forstner M, Ottl J, Mayr LM. Klumpp M, et al. Among authors: boettcher a. J Biomol Screen. 2006 Sep;11(6):617-33. doi: 10.1177/1087057106288444. Epub 2006 Jun 7. J Biomol Screen. 2006. PMID: 16760365

5

Knowledge-based virtual screening: application to the MDM4/p53 protein-protein interaction.

Jacoby E, Boettcher A, Mayr LM, Brown N, Jenkins JL, Kallen J, Engeloch C, Schopfer U, Furet P, Masuya K, Lisztwan J. Jacoby E, et al. Among authors: boettcher a. Methods Mol Biol. 2009;575:173-94. doi: 10.1007/978-1-60761-274-2_7. Methods Mol Biol. 2009. PMID: 19727615

6

Pharmacological inhibition of IKKβ dampens NLRP3 inflammasome activation after priming in the human myeloid cell line THP-1.

Unterreiner A, Rubert J, Kauffmann M, Fruhauf A, Heiser D, Erbel P, Schlapbach A, Eder J, Bodendorf U, Boettcher A, Farady CJ, Bornancin F. Unterreiner A, et al. Among authors: boettcher a. Biochem Biophys Res Commun. 2021 Mar 19;545:177-182. doi: 10.1016/j.bbrc.2021.01.051. Epub 2021 Feb 6. Biochem Biophys Res Commun. 2021. PMID: 33561652

7

Crystal Structure of NLRP3 NACHT Domain With an Inhibitor Defines Mechanism of Inflammasome Inhibition.

Dekker C, Mattes H, Wright M, Boettcher A, Hinniger A, Hughes N, Kapps-Fouthier S, Eder J, Erbel P, Stiefl N, Mackay A, Farady CJ. Dekker C, et al. Among authors: boettcher a. J Mol Biol. 2021 Dec 3;433(24):167309. doi: 10.1016/j.jmb.2021.167309. Epub 2021 Oct 20. J Mol Biol. 2021. PMID: 34687713

8

Clonal Hematopoiesis of Indeterminate Potential With Loss of Tet2 Enhances Risk for Atrial Fibrillation Through Nlrp3 Inflammasome Activation.

Lin AE, Bapat AC, Xiao L, Niroula A, Ye J, Wong WJ, Agrawal M, Farady CJ, Boettcher A, Hergott CB, McConkey M, Flores-Bringas P, Shkolnik V, Bick AG, Milan D, Natarajan P, Libby P, Ellinor PT, Ebert BL. Lin AE, et al. Among authors: boettcher a. Circulation. 2024 Apr 30;149(18):1419-1434. doi: 10.1161/CIRCULATIONAHA.123.065597. Epub 2024 Feb 15. Circulation. 2024. PMID: 38357791 Free PMC article.

9

Extrinsic and intrinsic apoptosis activate pannexin-1 to drive NLRP3 inflammasome assembly.

Chen KW, Demarco B, Heilig R, Shkarina K, Boettcher A, Farady CJ, Pelczar P, Broz P. Chen KW, et al. Among authors: boettcher a. EMBO J. 2019 May 15;38(10):e101638. doi: 10.15252/embj.2019101638. Epub 2019 Mar 22. EMBO J. 2019. PMID: 30902848 Free PMC article.

10

Discovery of Potent, Orally Bioavailable, Tricyclic NLRP3 Inhibitors.

Velcicky J, Janser P, Gommermann N, Brenneisen S, Ilic S, Vangrevelinghe E, Stiefl N, Boettcher A, Arnold C, Malinverni C, Dawson J, Murgasova R, Desrayaud S, Beltz K, Hinniger A, Dekker C, Farady CJ, Mackay A. Velcicky J, et al. Among authors: boettcher a. J Med Chem. 2024 Jan 25;67(2):1544-1562. doi: 10.1021/acs.jmedchem.3c02098. Epub 2024 Jan 4. J Med Chem. 2024. PMID: 38175811

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