De Clercq E - Search Results

1

Synthesis and anti-HIV evaluation of 2',3'-dideoxyribo-5-chloropyrimidine analogues: reduced toxicity of 5-chlorinated 2',3'-dideoxynucleosides.

Van Aerschot A, Everaert D, Balzarini J, Augustyns K, Jie L, Janssen G, Peeters O, Blaton N, De Ranter C, De Clercq E, et al. Van Aerschot A, et al. Among authors: de ranter c, de clercq e. J Med Chem. 1990 Jun;33(6):1833-9. doi: 10.1021/jm00168a046. J Med Chem. 1990. PMID: 2342078

2

3',3'-Difluoro-3'-deoxythymidine: comparison of anti-HIV activity to 3'-fluoro-3'-deoxythymidine.

Bergstrom DE, Mott AW, De Clercq E, Balzarini J, Swartling DJ. Bergstrom DE, et al. Among authors: de clercq e. J Med Chem. 1992 Sep 4;35(18):3369-72. doi: 10.1021/jm00096a011. J Med Chem. 1992. PMID: 1527788

3

5'-O-phosphonomethyl-2',3'-dideoxynucleosides: synthesis and anti-HIV activity.

Jie L, Van Aerschot A, Balzarini J, Janssen G, Busson R, Hoogmartens J, De Clercq E, Herdewijn P. Jie L, et al. Among authors: de clercq e. J Med Chem. 1990 Sep;33(9):2481-7. doi: 10.1021/jm00171a023. J Med Chem. 1990. PMID: 1697345

4

2'-Azido-2',3'-dideoxythymidine: synthesis and crystal structure of a 2'-substituted dideoxynucleoside.

Van Aerschot A, Everaert D, Gosselin G, Peeters O, Blaton N, De Ranter C, Imbach JL, Balzarini J, De Clercq E, Herdewijn P. Van Aerschot A, et al. Among authors: de ranter c, de clercq e. Antiviral Res. 1990 Dec;14(6):357-69. doi: 10.1016/0166-3542(90)90054-b. Antiviral Res. 1990. PMID: 2088211

5

Synthesis and antiviral activity of 3'-heterocyclic substituted 3'-deoxythymidines.

Wigerinck P, Van Aerschot A, Janssen G, Claes P, Balzarini J, De Clercq E, Herdewijn P. Wigerinck P, et al. Among authors: de clercq e. J Med Chem. 1990 Feb;33(2):868-73. doi: 10.1021/jm00164a063. J Med Chem. 1990. PMID: 2299650

6

Differential patterns of intracellular metabolism of 2',3'-didehydro-2',3'-dideoxythymidine and 3'-azido-2',3'-dideoxythymidine, two potent anti-human immunodeficiency virus compounds.

Balzarini J, Herdewijn P, De Clercq E. Balzarini J, et al. Among authors: de clercq e. J Biol Chem. 1989 Apr 15;264(11):6127-33. J Biol Chem. 1989. PMID: 2539371 Free article.

7

2',3'-didehydro-2',3'-dideoxy-5-chlorocytidine is a selective anti-retrovirus agent.

Balzarini J, Van Aerschot A, Herdewijn P, De Clercq E. Balzarini J, et al. Among authors: de clercq e. Biochem Biophys Res Commun. 1989 Nov 15;164(3):1190-7. doi: 10.1016/0006-291x(89)91795-6. Biochem Biophys Res Commun. 1989. PMID: 2590197

8

3'-Fluoro-2',3'-dideoxy-5-chlorouridine: most selective anti-HIV-1 agent among a series of new 2'- and 3'-fluorinated 2',3'-dideoxynucleoside analogues.

Van Aerschot A, Herdewijn P, Balzarini J, Pauwels R, De Clercq E. Van Aerschot A, et al. Among authors: de clercq e. J Med Chem. 1989 Aug;32(8):1743-9. doi: 10.1021/jm00128a013. J Med Chem. 1989. PMID: 2754700

9

Estimation of the lipophilicity of anti-HIV nucleoside analogues by determination of the partition coefficient and retention time on a Lichrospher 60 RP-8 HPLC column.

Balzarini J, Cools M, De Clercq E. Balzarini J, et al. Among authors: de clercq e. Biochem Biophys Res Commun. 1989 Jan 31;158(2):413-22. doi: 10.1016/s0006-291x(89)80063-4. Biochem Biophys Res Commun. 1989. PMID: 2916990

10

Synthesis and anti-HIV activity of different sugar-modified pyrimidine and purine nucleosides.

Herdewijn P, Balzarini J, Baba M, Pauwels R, Van Aerschot A, Janssen G, De Clercq E. Herdewijn P, et al. Among authors: de clercq e. J Med Chem. 1988 Oct;31(10):2040-8. doi: 10.1021/jm00118a033. J Med Chem. 1988. PMID: 3172142

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