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Dual Inhibition of MEK and PI3K/Akt Rescues Cancer Cachexia through both Tumor-Extrinsic and -Intrinsic Activities.
Talbert EE, Yang J, Mace TA, Farren MR, Farris AB, Young GS, Elnaggar O, Che Z, Timmers CD, Rajasekera P, Maskarinec JM, Bloomston M, Bekaii-Saab T, Guttridge DC, Lesinski GB. Talbert EE, et al. Among authors: guttridge dc. Mol Cancer Ther. 2017 Feb;16(2):344-356. doi: 10.1158/1535-7163.MCT-16-0337. Epub 2016 Nov 3. Mol Cancer Ther. 2017. PMID: 27811010 Free PMC article.
Circulating monocyte chemoattractant protein-1 (MCP-1) is associated with cachexia in treatment-naïve pancreatic cancer patients.
Talbert EE, Lewis HL, Farren MR, Ramsey ML, Chakedis JM, Rajasekera P, Haverick E, Sarna A, Bloomston M, Pawlik TM, Zimmers TA, Lesinski GB, Hart PA, Dillhoff ME, Schmidt CR, Guttridge DC. Talbert EE, et al. J Cachexia Sarcopenia Muscle. 2018 Apr;9(2):358-368. doi: 10.1002/jcsm.12251. Epub 2018 Jan 7. J Cachexia Sarcopenia Muscle. 2018. PMID: 29316343 Free PMC article.
Disruption of stromal hedgehog signaling initiates RNF5-mediated proteasomal degradation of PTEN and accelerates pancreatic tumor growth.
Pitarresi JR, Liu X, Avendano A, Thies KA, Sizemore GM, Hammer AM, Hildreth BE 3rd, Wang DJ, Steck SA, Donohue S, Cuitiño MC, Kladney RD, Mace TA, Chang JJ, Ennis CS, Li H, Reeves RH, Blackshaw S, Zhang J, Yu L, Fernandez SA, Frankel WL, Bloomston M, Rosol TJ, Lesinski GB, Konieczny SF, Guttridge DC, Rustgi AK, Leone G, Song JW, Wu J, Ostrowski MC. Pitarresi JR, et al. Among authors: guttridge dc. Life Sci Alliance. 2018 Oct 26;1(5):e201800190. doi: 10.26508/lsa.201800190. eCollection 2018 Oct. Life Sci Alliance. 2018. PMID: 30456390 Free PMC article.
Circulating interleukin-6 is associated with disease progression, but not cachexia in pancreatic cancer.
Ramsey ML, Talbert E, Ahn D, Bekaii-Saab T, Badi N, Bloomston PM, Conwell DL, Cruz-Monserrate Z, Dillhoff M, Farren MR, Hinton A, Krishna SG, Lesinski GB, Mace T, Manilchuk A, Noonan A, Pawlik TM, Rajasekera PV, Schmidt C, Guttridge D, Hart PA. Ramsey ML, et al. Among authors: guttridge d. Pancreatology. 2019 Jan;19(1):80-87. doi: 10.1016/j.pan.2018.11.002. Epub 2018 Nov 10. Pancreatology. 2019. PMID: 30497874 Free PMC article.
Epstein-Barr virus-encoded dUTPase enhances proinflammatory cytokine production by macrophages in contact with endothelial cells: evidence for depression-induced atherosclerotic risk.
Waldman WJ, Williams MV Jr, Lemeshow S, Binkley P, Guttridge D, Kiecolt-Glaser JK, Knight DA, Ladner KJ, Glaser R. Waldman WJ, et al. Among authors: guttridge d. Brain Behav Immun. 2008 Feb;22(2):215-23. doi: 10.1016/j.bbi.2007.07.007. Epub 2007 Sep 12. Brain Behav Immun. 2008. PMID: 17845840 Free PMC article.
150 results