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Page 1
Pharmacological characterization of GSK573719 (umeclidinium): a novel, long-acting, inhaled antagonist of the muscarinic cholinergic receptors for treatment of pulmonary diseases.
Salmon M, Luttmann MA, Foley JJ, Buckley PT, Schmidt DB, Burman M, Webb EF, DeHaas CJ, Kotzer CJ, Barrett VJ, Slack RJ, Sarau HM, Palovich MR, Lainé DI, Hay DW, Rumsey WL. Salmon M, et al. Among authors: palovich mr. J Pharmacol Exp Ther. 2013 May;345(2):260-70. doi: 10.1124/jpet.112.202051. Epub 2013 Feb 22. J Pharmacol Exp Ther. 2013. PMID: 23435542
Discovery of novel and long acting muscarinic acetylcholine receptor antagonists.
Jin J, Wang Y, Shi D, Wang F, Davis RS, Jin Q, Fu W, Foley JJ, Webb EF, Dehaas CJ, Berlanga M, Burman M, Sarau HM, Morrow DM, Rao P, Kallal LA, Moore ML, Rivero RA, Palovich M, Salmon M, Belmonte KE, Busch-Petersen J. Jin J, et al. J Med Chem. 2008 Aug 28;51(16):4866-9. doi: 10.1021/jm800634k. Epub 2008 Aug 5. J Med Chem. 2008. PMID: 18680280
Discovery of (3-endo)-3-(2-cyano-2,2-diphenylethyl)-8,8-dimethyl-8-azoniabicyclo[3.2.1]octane bromide as an efficacious inhaled muscarinic acetylcholine receptor antagonist for the treatment of COPD.
Wan Z, Laine DI, Yan H, Zhu C, Widdowson KL, Buckley PT, Burman M, Foley JJ, Sarau HM, Schmidt DB, Webb EF, Belmonte KE, Palovich M. Wan Z, et al. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4560-2. doi: 10.1016/j.bmcl.2009.07.006. Epub 2009 Jul 8. Bioorg Med Chem Lett. 2009. PMID: 19616944
Design, synthesis, and structure-activity relationship of tropane muscarinic acetylcholine receptor antagonists.
Lainé DI, Wan Z, Yan H, Zhu C, Xie H, Fu W, Busch-Petersen J, Neipp C, Davis R, Widdowson KL, Blaney FE, Foley J, Bacon AM, Webb EF, Luttmann MA, Burman M, Sarau HM, Salmon M, Palovich MR, Belmonte K. Lainé DI, et al. Among authors: palovich mr. J Med Chem. 2009 Aug 27;52(16):5241-52. doi: 10.1021/jm900736e. J Med Chem. 2009. PMID: 19630384
Design, synthesis and structure-activity relationship of N-substituted tropane muscarinic acetylcholine receptor antagonists.
Lainé DI, Yan H, Xie H, Davis RS, Dufour J, Widdowson KL, Palovich MR, Wan Z, Foley JJ, Schmidt DB, Hunsberger GE, Burman M, Bacon AM, Webb EF, Luttmann MA, Salmon M, Sarau HM, Umbrecht ST, Landis PS, Peck BJ, Busch-Petersen J. Lainé DI, et al. Among authors: palovich mr. Bioorg Med Chem Lett. 2012 May 1;22(9):3366-9. doi: 10.1016/j.bmcl.2012.02.015. Epub 2012 Feb 15. Bioorg Med Chem Lett. 2012. PMID: 22460029
Muscarinic acetylcholine receptor antagonists: SAR and optimization of tyrosine ureas.
Jin J, Wang Y, Shi D, Wang F, Fu W, Davis RS, Jin Q, Foley JJ, Sarau HM, Morrow DM, Moore ML, Rivero RA, Palovich M, Salmon M, Belmonte KE, Busch-Petersen J. Jin J, et al. Bioorg Med Chem Lett. 2008 Oct 15;18(20):5481-6. doi: 10.1016/j.bmcl.2008.09.020. Epub 2008 Sep 10. Bioorg Med Chem Lett. 2008. PMID: 18818072
N,N'-Diarylcyanoguanidines as antagonists of the CXCR2 and CXCR1 chemokine receptors.
Nie H, Widdowson KL, Palovich MR, Fu W, Elliott JD, Bryan DL, Burman M, Schmidt DB, Foley JJ, Sarau HM, Busch-Petersen J. Nie H, et al. Among authors: palovich mr. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5513-6. doi: 10.1016/j.bmcl.2006.08.042. Epub 2006 Aug 24. Bioorg Med Chem Lett. 2006. PMID: 16934456
18 results