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Design and synthesis of tetrahydropyridothieno[2,3-d]pyrimidine scaffold based epidermal growth factor receptor (EGFR) kinase inhibitors: the role of side chain chirality and Michael acceptor group for maximal potency.
Wu CH, Coumar MS, Chu CY, Lin WH, Chen YR, Chen CT, Shiao HY, Rafi S, Wang SY, Hsu H, Chen CH, Chang CY, Chang TY, Lien TW, Fang MY, Yeh KC, Chen CP, Yeh TK, Hsieh SH, Hsu JT, Liao CC, Chao YS, Hsieh HP. Wu CH, et al. Among authors: chang cy, chang ty. J Med Chem. 2010 Oct 28;53(20):7316-26. doi: 10.1021/jm100607r. J Med Chem. 2010. PMID: 20961149
Discovery of BPR1R024, an Orally Active and Selective CSF1R Inhibitor that Exhibits Antitumor and Immunomodulatory Activity in a Murine Colon Tumor Model.
Lee KH, Yen WC, Lin WH, Wang PC, Lai YL, Su YC, Chang CY, Wu CS, Huang YC, Yang CM, Chou LH, Yeh TK, Chen CT, Shih C, Hsieh HP. Lee KH, et al. Among authors: chang cy. J Med Chem. 2021 Oct 14;64(19):14477-14497. doi: 10.1021/acs.jmedchem.1c01006. Epub 2021 Oct 4. J Med Chem. 2021. PMID: 34606263 Free article.
Discovery of Dual MER/AXL Kinase Inhibitors as Bifunctional Small Molecules for Inhibiting Tumor Growth and Enhancing Tumor Immune Microenvironment.
Li MC, Lai YL, Kuo PH, Reddy JS, Chen CM, Manimala J, Wang PC, Wu MS, Chang CY, Yang CM, Lin CY, Huang YC, Chiu CH, Chang L, Lin WH, Yeh TK, Yen WC, Hsieh HP. Li MC, et al. Among authors: chang l, chang cy. J Med Chem. 2024 Jul 11;67(13):10906-10927. doi: 10.1021/acs.jmedchem.4c00400. Epub 2024 Jun 24. J Med Chem. 2024. PMID: 38913493 Free PMC article.
2,968 results