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A nonallergenic birch pollen allergy vaccine consisting of hepatitis PreS-fused Bet v 1 peptides focuses blocking IgG toward IgE epitopes and shifts immune responses to a tolerogenic and Th1 phenotype.
Marth K, Breyer I, Focke-Tejkl M, Blatt K, Shamji MH, Layhadi J, Gieras A, Swoboda I, Zafred D, Keller W, Valent P, Durham SR, Valenta R. Marth K, et al. Among authors: zafred d. J Immunol. 2013 Apr 1;190(7):3068-78. doi: 10.4049/jimmunol.1202441. Epub 2013 Feb 25. J Immunol. 2013. PMID: 23440415 Free PMC article.
Hypoallergenic derivatives of the major birch pollen allergen Bet v 1 obtained by rational sequence reassembly.
Campana R, Vrtala S, Maderegger B, Jertschin P, Stegfellner G, Swoboda I, Focke-Tejkl M, Blatt K, Gieras A, Zafred D, Neubauer A, Valent P, Keller W, Spitzauer S, Valenta R. Campana R, et al. Among authors: zafred d. J Allergy Clin Immunol. 2010 Nov;126(5):1024-31, 1031.e1-8. doi: 10.1016/j.jaci.2010.05.023. Epub 2010 Jul 16. J Allergy Clin Immunol. 2010. PMID: 20638112
Altered IgE epitope presentation: A model for hypoallergenic activity revealed for Bet v 1 trimer.
Campana R, Vrtala S, Maderegger B, Dall'Antonia Y, Zafred D, Blatt K, Herrmann H, Focke-Tejkl M, Swoboda I, Scheiblhofer S, Gieras A, Neubauer A, Keller W, Valent P, Thalhamer J, Spitzauer S, Valenta R. Campana R, et al. Among authors: zafred d. Mol Immunol. 2011 Jan;48(4):431-41. doi: 10.1016/j.molimm.2010.09.016. Epub 2010 Nov 18. Mol Immunol. 2011. PMID: 21093057 Free PMC article.
IgE epitope proximity determines immune complex shape and effector cell activation capacity.
Gieras A, Linhart B, Roux KH, Dutta M, Khodoun M, Zafred D, Cabauatan CR, Lupinek C, Weber M, Focke-Tejkl M, Keller W, Finkelman FD, Valenta R. Gieras A, et al. Among authors: zafred d. J Allergy Clin Immunol. 2016 May;137(5):1557-65. doi: 10.1016/j.jaci.2015.08.055. Epub 2015 Dec 10. J Allergy Clin Immunol. 2016. PMID: 26684291 Free PMC article.
Visualization of clustered IgE epitopes on alpha-lactalbumin.
Hochwallner H, Schulmeister U, Swoboda I, Focke-Tejkl M, Civaj V, Balic N, Nystrand M, Härlin A, Thalhamer J, Scheiblhofer S, Keller W, Pavkov T, Zafred D, Niggemann B, Quirce S, Mari A, Pauli G, Ebner C, Papadopoulos NG, Herz U, van Tol EA, Valenta R, Spitzauer S. Hochwallner H, et al. Among authors: zafred d. J Allergy Clin Immunol. 2010 Jun;125(6):1279-1285.e9. doi: 10.1016/j.jaci.2010.03.007. Epub 2010 May 13. J Allergy Clin Immunol. 2010. PMID: 20466413
14 results