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Liquid chromatography-mass spectrometry assay for quantitation of ifosfamide and its N-deschloroethylated metabolites in rat microsomal medium.
Storme T, Mercier L, Deroussent A, Re M, Martens T, Royer J, Bourget P, Vassal G, Paci A. Storme T, et al. Among authors: paci a. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Jun 25;820(2):251-9. doi: 10.1016/j.jchromb.2005.03.023. Epub 2005 Apr 25. J Chromatogr B Analyt Technol Biomed Life Sci. 2005. PMID: 15899378
Squalenoylation favorably modifies the in vivo pharmacokinetics and biodistribution of gemcitabine in mice.
Reddy LH, Khoury H, Paci A, Deroussent A, Ferreira H, Dubernet C, Declèves X, Besnard M, Chacun H, Lepêtre-Mouelhi S, Desmaële D, Rousseau B, Laugier C, Cintrat JC, Vassal G, Couvreur P. Reddy LH, et al. Among authors: paci a. Drug Metab Dispos. 2008 Aug;36(8):1570-7. doi: 10.1124/dmd.108.020735. Epub 2008 May 12. Drug Metab Dispos. 2008. PMID: 18474674
New ifosfamide analogs designed for lower associated neurotoxicity and nephrotoxicity with modified alkylating kinetics leading to enhanced in vitro anticancer activity.
Storme T, Deroussent A, Mercier L, Prost E, Re M, Munier F, Martens T, Bourget P, Vassal G, Royer J, Paci A. Storme T, et al. Among authors: paci a. J Pharmacol Exp Ther. 2009 Feb;328(2):598-609. doi: 10.1124/jpet.108.144170. Epub 2008 Nov 18. J Pharmacol Exp Ther. 2009. PMID: 19017849
326 results