Cogoi S - Search Results

1

Guanidino anthrathiophenediones as G-quadruplex binders: uptake, intracellular localization, and anti-Harvey-Ras gene activity in bladder cancer cells.

Cogoi S, Shchekotikhin AE, Membrino A, Sinkevich YB, Xodo LE. Cogoi S, et al. J Med Chem. 2013 Apr 11;56(7):2764-78. doi: 10.1021/jm3019063. Epub 2013 Mar 21. J Med Chem. 2013. PMID: 23458775

2

Identification of a new G-quadruplex motif in the KRAS promoter and design of pyrene-modified G4-decoys with antiproliferative activity in pancreatic cancer cells.

Cogoi S, Paramasivam M, Filichev V, Géci I, Pedersen EB, Xodo LE. Cogoi S, et al. J Med Chem. 2009 Jan 22;52(2):564-8. doi: 10.1021/jm800874t. J Med Chem. 2009. PMID: 19099510

3

The KRAS promoter responds to Myc-associated zinc finger and poly(ADP-ribose) polymerase 1 proteins, which recognize a critical quadruplex-forming GA-element.

Cogoi S, Paramasivam M, Membrino A, Yokoyama KK, Xodo LE. Cogoi S, et al. J Biol Chem. 2010 Jul 16;285(29):22003-16. doi: 10.1074/jbc.M110.101923. Epub 2010 May 10. J Biol Chem. 2010. PMID: 20457603 Free PMC article.

4

G4-DNA formation in the HRAS promoter and rational design of decoy oligonucleotides for cancer therapy.

Membrino A, Cogoi S, Pedersen EB, Xodo LE. Membrino A, et al. Among authors: cogoi s. PLoS One. 2011;6(9):e24421. doi: 10.1371/journal.pone.0024421. Epub 2011 Sep 8. PLoS One. 2011. PMID: 21931711 Free PMC article.

5

HRAS is silenced by two neighboring G-quadruplexes and activated by MAZ, a zinc-finger transcription factor with DNA unfolding property.

Cogoi S, Shchekotikhin AE, Xodo LE. Cogoi S, et al. Nucleic Acids Res. 2014 Jul;42(13):8379-88. doi: 10.1093/nar/gku574. Epub 2014 Jul 10. Nucleic Acids Res. 2014. PMID: 25013182 Free PMC article.

6

Potent Apoptotic Response Induced by Chloroacetamidine Anthrathiophenediones in Bladder Cancer Cells.

Cogoi S, Zorzet S, Shchekotikhin AE, Xodo LE. Cogoi S, et al. J Med Chem. 2015 Jul 23;58(14):5476-85. doi: 10.1021/acs.jmedchem.5b00409. Epub 2015 Jun 30. J Med Chem. 2015. PMID: 26057859 Free article.

7

Nucleic Acid Targeted Therapy: G4 Oligonucleotides Downregulate HRAS in Bladder Cancer Cells through a Decoy Mechanism.

Miglietta G, Gouda AS, Cogoi S, Pedersen EB, Xodo LE. Miglietta G, et al. Among authors: cogoi s. ACS Med Chem Lett. 2015 Oct 18;6(12):1179-83. doi: 10.1021/acsmedchemlett.5b00315. eCollection 2015 Dec 10. ACS Med Chem Lett. 2015. PMID: 26713101 Free PMC article.

8

Photosensitizers binding to nucleic acids as anticancer agents.

Xodo LE, Cogoi S, Rapozzi V. Xodo LE, et al. Among authors: cogoi s. Future Med Chem. 2016;8(2):179-94. doi: 10.4155/fmc.15.180. Epub 2016 Jan 25. Future Med Chem. 2016. PMID: 26807879 Review.

9

RNA G-Quadruplexes in Kirsten Ras (KRAS) Oncogene as Targets for Small Molecules Inhibiting Translation.

Miglietta G, Cogoi S, Marinello J, Capranico G, Tikhomirov AS, Shchekotikhin A, Xodo LE. Miglietta G, et al. Among authors: cogoi s. J Med Chem. 2017 Dec 14;60(23):9448-9461. doi: 10.1021/acs.jmedchem.7b00622. Epub 2017 Dec 1. J Med Chem. 2017. PMID: 29140695

10

Cellular uptake and binding of guanidine-modified phthalocyanines to KRAS/HRAS G-quadruplexes.

Membrino A, Paramasivam M, Cogoi S, Alzeer J, Luedtke NW, Xodo LE. Membrino A, et al. Among authors: cogoi s. Chem Commun (Camb). 2010 Jan 28;46(4):625-7. doi: 10.1039/b918964e. Epub 2009 Nov 20. Chem Commun (Camb). 2010. PMID: 20062883 Free article.

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