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Gene knockout of 5-lipoxygenase rescues synaptic dysfunction and improves memory in the triple-transgenic model of Alzheimer's disease.
Giannopoulos PF, Chu J, Joshi YB, Sperow M, Li JG, Kirby LG, Praticò D. Giannopoulos PF, et al. Among authors: kirby lg. Mol Psychiatry. 2014 Apr;19(4):511-8. doi: 10.1038/mp.2013.23. Epub 2013 Mar 12. Mol Psychiatry. 2014. Retraction in: Mol Psychiatry. 2023 Feb;28(2):964. doi: 10.1038/s41380-022-01813-2 PMID: 23478745 Free PMC article. Retracted.
5-lipoxygenase activating protein reduction ameliorates cognitive deficit, synaptic dysfunction, and neuropathology in a mouse model of Alzheimer's disease.
Giannopoulos PF, Chu J, Joshi YB, Sperow M, Li JG, Kirby LG, Praticò D. Giannopoulos PF, et al. Among authors: kirby lg. Biol Psychiatry. 2013 Sep 1;74(5):348-56. doi: 10.1016/j.biopsych.2013.04.009. Epub 2013 May 15. Biol Psychiatry. 2013. Retraction in: Biol Psychiatry. 2024 Jul 15;96(2):160. doi: 10.1016/j.biopsych.2024.05.001 PMID: 23683389 Free PMC article. Retracted.
Absence of ALOX5 gene prevents stress-induced memory deficits, synaptic dysfunction and tauopathy in a mouse model of Alzheimer's disease.
Joshi YB, Giannopoulos PF, Chu J, Sperow M, Kirby LG, Abood ME, Praticò D. Joshi YB, et al. Among authors: kirby lg. Hum Mol Genet. 2014 Dec 20;23(25):6894-902. doi: 10.1093/hmg/ddu412. Epub 2014 Aug 13. Hum Mol Genet. 2014. Retraction in: Hum Mol Genet. 2024 Aug 15:ddae114. doi: 10.1093/hmg/ddae114 PMID: 25122659 Free PMC article. Retracted.
Pharmacologic inhibition of 5-lipoxygenase improves memory, rescues synaptic dysfunction, and ameliorates tau pathology in a transgenic model of tauopathy.
Giannopoulos PF, Chu J, Sperow M, Li JG, Yu WH, Kirby LG, Abood M, Praticò D. Giannopoulos PF, et al. Among authors: kirby lg. Biol Psychiatry. 2015 Nov 15;78(10):693-701. doi: 10.1016/j.biopsych.2015.01.015. Epub 2015 Feb 7. Biol Psychiatry. 2015. Retraction in: Biol Psychiatry. 2024 Jul 15;96(2):160. doi: 10.1016/j.biopsych.2024.05.002 PMID: 25802082 Free PMC article. Retracted.
52 results