Miyaguchi I - Search Results

1

A comparative study of the binding modes of recently launched dipeptidyl peptidase IV inhibitors in the active site.

Nabeno M, Akahoshi F, Kishida H, Miyaguchi I, Tanaka Y, Ishii S, Kadowaki T. Nabeno M, et al. Among authors: miyaguchi i. Biochem Biophys Res Commun. 2013 May 3;434(2):191-6. doi: 10.1016/j.bbrc.2013.03.010. Epub 2013 Mar 15. Biochem Biophys Res Commun. 2013. PMID: 23501107

2

Fused bicyclic heteroarylpiperazine-substituted L-prolylthiazolidines as highly potent DPP-4 inhibitors lacking the electrophilic nitrile group.

Yoshida T, Akahoshi F, Sakashita H, Sonda S, Takeuchi M, Tanaka Y, Nabeno M, Kishida H, Miyaguchi I, Hayashi Y. Yoshida T, et al. Among authors: miyaguchi i. Bioorg Med Chem. 2012 Aug 15;20(16):5033-41. doi: 10.1016/j.bmc.2012.06.033. Epub 2012 Jul 5. Bioorg Med Chem. 2012. PMID: 22824762

3

Discovery and preclinical profile of teneligliptin (3-[(2S,4S)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]pyrrolidin-2-ylcarbonyl]thiazolidine): a highly potent, selective, long-lasting and orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.

Yoshida T, Akahoshi F, Sakashita H, Kitajima H, Nakamura M, Sonda S, Takeuchi M, Tanaka Y, Ueda N, Sekiguchi S, Ishige T, Shima K, Nabeno M, Abe Y, Anabuki J, Soejima A, Yoshida K, Takashina Y, Ishii S, Kiuchi S, Fukuda S, Tsutsumiuchi R, Kosaka K, Murozono T, Nakamaru Y, Utsumi H, Masutomi N, Kishida H, Miyaguchi I, Hayashi Y. Yoshida T, et al. Among authors: miyaguchi i. Bioorg Med Chem. 2012 Oct 1;20(19):5705-19. doi: 10.1016/j.bmc.2012.08.012. Epub 2012 Aug 17. Bioorg Med Chem. 2012. PMID: 22959556

4

Transport and inhibition mechanism of the human SGLT2-MAP17 glucose transporter.

Hiraizumi M, Akashi T, Murasaki K, Kishida H, Kumanomidou T, Torimoto N, Nureki O, Miyaguchi I. Hiraizumi M, et al. Among authors: miyaguchi i. Nat Struct Mol Biol. 2024 Jan;31(1):159-169. doi: 10.1038/s41594-023-01134-0. Epub 2023 Dec 6. Nat Struct Mol Biol. 2024. PMID: 38057552 Free PMC article.

5

Machine learning to estimate the local quality of protein crystal structures.

Miyaguchi I, Sato M, Kashima A, Nakagawa H, Kokabu Y, Ma B, Matsumoto S, Tokuhisa A, Ohta M, Ikeguchi M. Miyaguchi I, et al. Sci Rep. 2021 Dec 8;11(1):23599. doi: 10.1038/s41598-021-02948-y. Sci Rep. 2021. PMID: 34880321 Free PMC article.

6

Discovery of a potent orally available pyrazolopyridone derivative as a novel selective bromodomain and extra-terminal domain (BET)-first bromodomain (BD1) inhibitor.

Hagihara S, Ishizawa K, Soga K, Honjo T, Takai S, Kawano Y, Kikuchi M, Nishidate A, Matsumoto F, Murase M, Hashimoto N, Sasaki C, Miyaguchi I, Okada O, Akashi T, Nakayama S, Ogasawara Y, Endo J. Hagihara S, et al. Among authors: miyaguchi i. Bioorg Med Chem Lett. 2024 Sep 1;109:129849. doi: 10.1016/j.bmcl.2024.129849. Epub 2024 Jun 12. Bioorg Med Chem Lett. 2024. PMID: 38876177

7

Discovery of a potent, orally available furopyridine derivative as a novel selective bromodomain and extra-terminal domain (BET)-first bromodomain (BD1) inhibitor.

Hagihara S, Ishizawa K, Kikuchi M, Kawano Y, Nishidate A, Matsumoto F, Hashimoto N, Sasaki C, Miyaguchi I, Okada O, Akashi T, Nakayama S, Ogasawara Y, Endo J. Hagihara S, et al. Among authors: miyaguchi i. Bioorg Med Chem Lett. 2024 Sep 1;109:129848. doi: 10.1016/j.bmcl.2024.129848. Epub 2024 Jun 12. Bioorg Med Chem Lett. 2024. PMID: 38876176

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