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Page 1
Discovery and preclinical profile of teneligliptin (3-[(2S,4S)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]pyrrolidin-2-ylcarbonyl]thiazolidine): a highly potent, selective, long-lasting and orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.
Yoshida T, Akahoshi F, Sakashita H, Kitajima H, Nakamura M, Sonda S, Takeuchi M, Tanaka Y, Ueda N, Sekiguchi S, Ishige T, Shima K, Nabeno M, Abe Y, Anabuki J, Soejima A, Yoshida K, Takashina Y, Ishii S, Kiuchi S, Fukuda S, Tsutsumiuchi R, Kosaka K, Murozono T, Nakamaru Y, Utsumi H, Masutomi N, Kishida H, Miyaguchi I, Hayashi Y. Yoshida T, et al. Among authors: nabeno m. Bioorg Med Chem. 2012 Oct 1;20(19):5705-19. doi: 10.1016/j.bmc.2012.08.012. Epub 2012 Aug 17. Bioorg Med Chem. 2012. PMID: 22959556
Discovery of novel 2-(4-aryl-2-methylpiperazin-1-yl)-pyrimidin-4-ones as glycogen synthase kinase-3β inhibitors.
Kohara T, Nakayama K, Watanabe K, Kusaka SI, Sakai D, Tanaka H, Fukunaga K, Sunada S, Nabeno M, Saito KI, Eguchi JI, Mori A, Tanaka S, Bessho T, Takiguchi-Hayashi K, Horikawa T. Kohara T, et al. Among authors: nabeno m. Bioorg Med Chem Lett. 2017 Aug 15;27(16):3733-3738. doi: 10.1016/j.bmcl.2017.06.077. Epub 2017 Jul 5. Bioorg Med Chem Lett. 2017. PMID: 28712706
Discovery of novel 2-(3-phenylpiperazin-1-yl)-pyrimidin-4-ones as glycogen synthase kinase-3β inhibitors.
Usui Y, Uehara F, Hiki S, Watanabe K, Tanaka H, Shouda A, Yokoshima S, Aritomo K, Adachi T, Fukunaga K, Sunada S, Nabeno M, Saito KI, Eguchi JI, Yamagami K, Asano S, Tanaka S, Yuki S, Yoshii N, Fujimura M, Horikawa T. Usui Y, et al. Among authors: nabeno m. Bioorg Med Chem Lett. 2017 Aug 15;27(16):3726-3732. doi: 10.1016/j.bmcl.2017.06.078. Epub 2017 Jul 5. Bioorg Med Chem Lett. 2017. PMID: 28712708
Discovery of novel 2-(alkylmorpholin-4-yl)-6-(3-fluoropyridin-4-yl)-pyrimidin-4(3H)-ones as orally-active GSK-3β inhibitors for Alzheimer's disease.
Fukunaga K, Sakai D, Watanabe K, Nakayama K, Kohara T, Tanaka H, Sunada S, Nabeno M, Okamoto M, Saito K, Eguchi J, Mori A, Tanaka S, Inazawa K, Horikawa T. Fukunaga K, et al. Among authors: nabeno m. Bioorg Med Chem Lett. 2015 Mar 1;25(5):1086-91. doi: 10.1016/j.bmcl.2015.01.005. Epub 2015 Jan 13. Bioorg Med Chem Lett. 2015. PMID: 25655721