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Increased neuronal PreP activity reduces Aβ accumulation, attenuates neuroinflammation and improves mitochondrial and synaptic function in Alzheimer disease's mouse model.
Fang D, Wang Y, Zhang Z, Du H, Yan S, Sun Q, Zhong C, Wu L, Vangavaragu JR, Yan S, Hu G, Guo L, Rabinowitz M, Glaser E, Arancio O, Sosunov AA, McKhann GM, Chen JX, Yan SS. Fang D, et al. Among authors: sosunov aa. Hum Mol Genet. 2015 Sep 15;24(18):5198-210. doi: 10.1093/hmg/ddv241. Epub 2015 Jun 29. Hum Mol Genet. 2015. PMID: 26123488 Free PMC article.
RAGE-mediated signaling contributes to intraneuronal transport of amyloid-beta and neuronal dysfunction.
Takuma K, Fang F, Zhang W, Yan S, Fukuzaki E, Du H, Sosunov A, McKhann G, Funatsu Y, Nakamichi N, Nagai T, Mizoguchi H, Ibi D, Hori O, Ogawa S, Stern DM, Yamada K, Yan SS. Takuma K, et al. Proc Natl Acad Sci U S A. 2009 Nov 24;106(47):20021-6. doi: 10.1073/pnas.0905686106. Epub 2009 Nov 9. Proc Natl Acad Sci U S A. 2009. PMID: 19901339 Free PMC article.
88 results