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Apolipoprotein E/Amyloid-β Complex Accumulates in Alzheimer Disease Cortical Synapses via Apolipoprotein E Receptors and Is Enhanced by APOE4.
Bilousova T, Melnik M, Miyoshi E, Gonzalez BL, Poon WW, Vinters HV, Miller CA, Corrada MM, Kawas C, Hatami A, Albay R 3rd, Glabe C, Gylys KH. Bilousova T, et al. Among authors: albay r 3rd. Am J Pathol. 2019 Aug;189(8):1621-1636. doi: 10.1016/j.ajpath.2019.04.010. Epub 2019 May 17. Am J Pathol. 2019. PMID: 31108099 Free PMC article.
Early long-term administration of the CSF1R inhibitor PLX3397 ablates microglia and reduces accumulation of intraneuronal amyloid, neuritic plaque deposition and pre-fibrillar oligomers in 5XFAD mouse model of Alzheimer's disease.
Sosna J, Philipp S, Albay R 3rd, Reyes-Ruiz JM, Baglietto-Vargas D, LaFerla FM, Glabe CG. Sosna J, et al. Among authors: albay r 3rd. Mol Neurodegener. 2018 Mar 1;13(1):11. doi: 10.1186/s13024-018-0244-x. Mol Neurodegener. 2018. PMID: 29490706 Free PMC article.
Intracellular amyloid and the neuronal origin of Alzheimer neuritic plaques.
Pensalfini A, Albay R 3rd, Rasool S, Wu JW, Hatami A, Arai H, Margol L, Milton S, Poon WW, Corrada MM, Kawas CH, Glabe CG. Pensalfini A, et al. Among authors: albay r 3rd. Neurobiol Dis. 2014 Nov;71:53-61. doi: 10.1016/j.nbd.2014.07.011. Epub 2014 Aug 1. Neurobiol Dis. 2014. PMID: 25092575 Free PMC article.
Vaccination with a non-human random sequence amyloid oligomer mimic results in improved cognitive function and reduced plaque deposition and micro hemorrhage in Tg2576 mice.
Rasool S, Albay R 3rd, Martinez-Coria H, Breydo L, Wu J, Milton S, Misra S, Tran A, Pensalfini A, Laferla F, Kayed R, Glabe CG. Rasool S, et al. Among authors: albay r 3rd. Mol Neurodegener. 2012 Aug 6;7:37. doi: 10.1186/1750-1326-7-37. Mol Neurodegener. 2012. PMID: 22866920 Free PMC article.