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Targeting the endocannabinoid system in the treatment of fragile X syndrome.
Busquets-Garcia A, Gomis-González M, Guegan T, Agustín-Pavón C, Pastor A, Mato S, Pérez-Samartín A, Matute C, de la Torre R, Dierssen M, Maldonado R, Ozaita A. Busquets-Garcia A, et al. Among authors: dierssen m. Nat Med. 2013 May;19(5):603-7. doi: 10.1038/nm.3127. Epub 2013 Mar 31. Nat Med. 2013. PMID: 23542787
Down syndrome: the brain in trisomic mode.
Dierssen M. Dierssen M. Nat Rev Neurosci. 2012 Dec;13(12):844-58. doi: 10.1038/nrn3314. Nat Rev Neurosci. 2012. PMID: 23165261 Review.
A phase 1, randomized double-blind, placebo controlled trial to evaluate safety and efficacy of epigallocatechin-3-gallate and cognitive training in adults with Fragile X syndrome.
de la Torre R, de Sola S, Farré M, Xicota L, Cuenca-Royo A, Rodriguez J, León A, Langohr K, Gomis-González M, Hernandez G, Esteba S, Del Hoyo L, Sánchez-Gutiérrez J, Cortés MJ, Ozaita A, Espadaler JM, Novell R, Martínez-Leal R, Milá M, Dierssen M; TESXF Study Group. de la Torre R, et al. Among authors: dierssen m. Clin Nutr. 2020 Feb;39(2):378-387. doi: 10.1016/j.clnu.2019.02.028. Epub 2019 Mar 25. Clin Nutr. 2020. PMID: 30962103 Clinical Trial.
Transgenic mice overexpressing the full-length neurotrophin receptor TrkC exhibit increased catecholaminergic neuron density in specific brain areas and increased anxiety-like behavior and panic reaction.
Dierssen M, Gratacòs M, Sahún I, Martín M, Gallego X, Amador-Arjona A, Martínez de Lagrán M, Murtra P, Martí E, Pujana MA, Ferrer I, Dalfó E, Martínez-Cué C, Flórez J, Torres-Peraza JF, Alberch J, Maldonado R, Fillat C, Estivill X. Dierssen M, et al. Neurobiol Dis. 2006 Nov;24(2):403-18. doi: 10.1016/j.nbd.2006.07.015. Epub 2006 Sep 11. Neurobiol Dis. 2006. PMID: 16963267
Increased opioid dependence in a mouse model of panic disorder.
Gallego X, Murtra P, Zamalloa T, Canals JM, Pineda J, Amador-Arjona A, Maldonado R, Dierssen M. Gallego X, et al. Among authors: dierssen m. Front Behav Neurosci. 2010 Feb 22;3:60. doi: 10.3389/neuro.08.060.2009. eCollection 2010. Front Behav Neurosci. 2010. PMID: 20204153 Free PMC article.
Overexpression of Reelin prevents the manifestation of behavioral phenotypes related to schizophrenia and bipolar disorder.
Teixeira CM, Martín ED, Sahún I, Masachs N, Pujadas L, Corvelo A, Bosch C, Rossi D, Martinez A, Maldonado R, Dierssen M, Soriano E. Teixeira CM, et al. Among authors: dierssen m. Neuropsychopharmacology. 2011 Nov;36(12):2395-405. doi: 10.1038/npp.2011.153. Epub 2011 Aug 3. Neuropsychopharmacology. 2011. PMID: 21814183 Free PMC article.
Overexpression of the CHRNA5/A3/B4 genomic cluster in mice increases the sensitivity to nicotine and modifies its reinforcing effects.
Gallego X, Molas S, Amador-Arjona A, Marks MJ, Robles N, Murtra P, Armengol L, Fernández-Montes RD, Gratacòs M, Pumarola M, Cabrera R, Maldonado R, Sabrià J, Estivill X, Dierssen M. Gallego X, et al. Among authors: dierssen m. Amino Acids. 2012 Aug;43(2):897-909. doi: 10.1007/s00726-011-1149-y. Epub 2011 Nov 19. Amino Acids. 2012. PMID: 22101982
DREAM controls the on/off switch of specific activity-dependent transcription pathways.
Mellström B, Sahún I, Ruiz-Nuño A, Murtra P, Gomez-Villafuertes R, Savignac M, Oliveros JC, Gonzalez P, Kastanauskaite A, Knafo S, Zhuo M, Higuera-Matas A, Errington ML, Maldonado R, DeFelipe J, Jefferys JG, Bliss TV, Dierssen M, Naranjo JR. Mellström B, et al. Among authors: dierssen m. Mol Cell Biol. 2014 Mar;34(5):877-87. doi: 10.1128/MCB.00360-13. Epub 2013 Dec 23. Mol Cell Biol. 2014. PMID: 24366545 Free PMC article.
232 results