Chłoń-Rzepa G - Search Results

1

New 8-aminoalkyl derivatives of purine-2,6-dione with arylalkyl, allyl or propynyl substituents in position 7, their 5-HT1A, 5-HT2A, and 5-HT7 receptor affinity and pharmacological evaluation.

Chłoń-Rzepa G, Zmudzki P, Satała G, Duszyńska B, Partyka A, Wróbel D, Jastrzębska-Więsek M, Wesołowska A, Bojarski AJ, Pawłowski M, Zajdel P. Chłoń-Rzepa G, et al. Pharmacol Rep. 2013;65(1):15-29. doi: 10.1016/s1734-1140(13)70960-5. Pharmacol Rep. 2013. PMID: 23563020 Free article.

2

Preliminary study on application of impregnated synthetic peptide TLC stationary phases for the pre-screening of 5-HT1A ligands.

Zajdel P, Bojarski AJ, Byrtus H, Chłoń-Rzepa G, Obniska J, Chevallet P, Martinez J, Pawłowski M. Zajdel P, et al. Biomed Chromatogr. 2003 Jul;17(5):312-7. doi: 10.1002/bmc.224. Biomed Chromatogr. 2003. PMID: 12884396

3

Synthesis and cardiovascular activity of new 8-alkylamino-1,3-dimethyl-7-(2-hydroxy-3- piperazinopropyl)-3,7-dihydro-1H-purine-2,6-diones.

Chłoń-Rzepa G, Pawłowski M, Zygmunt M, Filipek B, Maciag D. Chłoń-Rzepa G, et al. Pol J Pharmacol. 2004 Nov-Dec;56(6):755-66. Pol J Pharmacol. 2004. PMID: 15662088 Free article.

4

7-Arylpiperazinylalkyl and 7-tetrahydroisoquinolinylalkyl derivatives of 8-alkoxy-purine-2,6-dione and some of their purine-2,6,8-trione analogs as 5-HT(1A), 5-HT(2A), and 5-HT(7) serotonin receptor ligands.

Chłoń-Rzepa G, Zmudzki P, Zajdel P, Bojarski AJ, Duszyńska B, Nikiforuk A, Tatarczyńska E, Pawłowski M. Chłoń-Rzepa G, et al. Bioorg Med Chem. 2007 Aug 1;15(15):5239-50. doi: 10.1016/j.bmc.2007.05.017. Epub 2007 May 10. Bioorg Med Chem. 2007. PMID: 17517514

5

Structure-cardiovascular activity relationships in a group of new 8-alkylamino-1,3-dimethyl-7-(2-hydroxy-3-aminopropyl)-3,7-dihydro-1H-purine-2,6-diones.

Chłoń-Rzepa G, Zmudzki P, Pawłowski M, Zygmunt M, Filipek B. Chłoń-Rzepa G, et al. Pharmacol Rep. 2011;63(2):476-86. doi: 10.1016/s1734-1140(11)70514-x. Pharmacol Rep. 2011. PMID: 21602603 Free article.

6

7-3-Chlorophenypiperazinylalkyl derivatives of 8-alkoxy-purine-2,6-dione as a serotonin receptor ligands with potential antidepressant activity.

Zygmunt M, Sapa J, Chłoń-Rzepa G, Zagórska A, Siwek A, Pawłowski M, Nowak G. Zygmunt M, et al. Pharmacol Rep. 2014 Jun;66(3):505-10. doi: 10.1016/j.pharep.2013.12.014. Epub 2014 Apr 13. Pharmacol Rep. 2014. PMID: 24905531

7

Antidepressant- and anxiolytic-like activity of 7-phenylpiperazinylalkyl-1,3-dimethyl-purine-2,6-dione derivatives with diversified 5-HT₁A receptor functional profile.

Partyka A, Chłoń-Rzepa G, Wasik A, Jastrzębska-Więsek M, Bucki A, Kołaczkowski M, Satała G, Bojarski AJ, Wesołowska A. Partyka A, et al. Bioorg Med Chem. 2015 Jan 1;23(1):212-21. doi: 10.1016/j.bmc.2014.11.008. Epub 2014 Nov 11. Bioorg Med Chem. 2015. PMID: 25435254

8

Analgesic and anti-inflammatory activity of 7-substituted purine-2,6-diones.

Zygmunt M, Chłoń-Rzepa G, Sapa J. Zygmunt M, et al. Pharmacol Rep. 2014 Dec;66(6):996-1002. doi: 10.1016/j.pharep.2014.06.015. Epub 2014 Jun 28. Pharmacol Rep. 2014. PMID: 25443727

9

Analgesic activity of new 8-methoxy-1,3-dimethyl-2,6-dioxo-purin-7-yl derivatives with carboxylic, ester or amide moieties.

Zygmunt M, Chłoń-Rzepa G, Sapa J, Pawłowski M. Zygmunt M, et al. Pharmacol Rep. 2015 Feb;67(1):9-16. doi: 10.1016/j.pharep.2014.07.018. Epub 2014 Aug 13. Pharmacol Rep. 2015. PMID: 25560569

10

Structure-5-HT receptor affinity relationship in a new group of 7-arylpiperazynylalkyl and 7-tetrahydroisoquinolinylalkyl derivatives of 8-amino-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione.

Żmudzki P, Chłoń-Rzepa G, Bojarski AJ, Zygmunt M, Kazek G, Mordyl B, Pawłowski M. Żmudzki P, et al. Arch Pharm (Weinheim). 2015 Apr;348(4):229-41. doi: 10.1002/ardp.201400392. Epub 2015 Mar 13. Arch Pharm (Weinheim). 2015. PMID: 25773578

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