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Decreased nucleotide excision repair activity and alterations of topoisomerase IIalpha are associated with the in vivo resistance of a P388 leukemia subline to F11782, a novel catalytic inhibitor of topoisomerases I and II.
Kruczynski A, Barret JM, Van Hille B, Chansard N, Astruc J, Menon Y, Duchier C, Créancier L, Hill BT. Kruczynski A, et al. Among authors: creancier l. Clin Cancer Res. 2004 May 1;10(9):3156-68. doi: 10.1158/1078-0432.ccr-1305-2. Clin Cancer Res. 2004. PMID: 15131057
Triptolide is an inhibitor of RNA polymerase I and II-dependent transcription leading predominantly to down-regulation of short-lived mRNA.
Vispé S, DeVries L, Créancier L, Besse J, Bréand S, Hobson DJ, Svejstrup JQ, Annereau JP, Cussac D, Dumontet C, Guilbaud N, Barret JM, Bailly C. Vispé S, et al. Among authors: creancier l. Mol Cancer Ther. 2009 Oct;8(10):2780-90. doi: 10.1158/1535-7163.MCT-09-0549. Epub 2009 Oct 6. Mol Cancer Ther. 2009. PMID: 19808979
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