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High-level semi-synthetic production of the potent antimalarial artemisinin.
Paddon CJ, Westfall PJ, Pitera DJ, Benjamin K, Fisher K, McPhee D, Leavell MD, Tai A, Main A, Eng D, Polichuk DR, Teoh KH, Reed DW, Treynor T, Lenihan J, Fleck M, Bajad S, Dang G, Dengrove D, Diola D, Dorin G, Ellens KW, Fickes S, Galazzo J, Gaucher SP, Geistlinger T, Henry R, Hepp M, Horning T, Iqbal T, Jiang H, Kizer L, Lieu B, Melis D, Moss N, Regentin R, Secrest S, Tsuruta H, Vazquez R, Westblade LF, Xu L, Yu M, Zhang Y, Zhao L, Lievense J, Covello PS, Keasling JD, Reiling KK, Renninger NS, Newman JD. Paddon CJ, et al. Among authors: tsuruta h. Nature. 2013 Apr 25;496(7446):528-32. doi: 10.1038/nature12051. Epub 2013 Apr 10. Nature. 2013. PMID: 23575629
Production of amorphadiene in yeast, and its conversion to dihydroartemisinic acid, precursor to the antimalarial agent artemisinin.
Westfall PJ, Pitera DJ, Lenihan JR, Eng D, Woolard FX, Regentin R, Horning T, Tsuruta H, Melis DJ, Owens A, Fickes S, Diola D, Benjamin KR, Keasling JD, Leavell MD, McPhee DJ, Renninger NS, Newman JD, Paddon CJ. Westfall PJ, et al. Among authors: tsuruta h. Proc Natl Acad Sci U S A. 2012 Jan 17;109(3):E111-8. doi: 10.1073/pnas.1110740109. Epub 2012 Jan 12. Proc Natl Acad Sci U S A. 2012. PMID: 22247290 Free PMC article.
Modulation of epothilone analog production through media design.
Frykman S, Tsuruta H, Lau J, Regentin R, Ou S, Reeves C, Carney J, Santi D, Licari P. Frykman S, et al. Among authors: tsuruta h. J Ind Microbiol Biotechnol. 2002 Jan;28(1):17-20. doi: 10.1038/sj/jim/7000209. J Ind Microbiol Biotechnol. 2002. PMID: 11938466
398 results