Hegarty JE - Search Results

1

Hepatitis C virus targets the interferon-α JAK/STAT pathway by promoting proteasomal degradation in immune cells and hepatocytes.

Stevenson NJ, Bourke NM, Ryan EJ, Binder M, Fanning L, Johnston JA, Hegarty JE, Long A, O'Farrelly C. Stevenson NJ, et al. Among authors: hegarty je. FEBS Lett. 2013 May 21;587(10):1571-8. doi: 10.1016/j.febslet.2013.03.041. Epub 2013 Apr 12. FEBS Lett. 2013. PMID: 23587486 Free article.

2

Ribavirin enhances IFN-α signalling and MxA expression: a novel immune modulation mechanism during treatment of HCV.

Stevenson NJ, Murphy AG, Bourke NM, Keogh CA, Hegarty JE, O'Farrelly C. Stevenson NJ, et al. Among authors: hegarty je. PLoS One. 2011;6(11):e27866. doi: 10.1371/journal.pone.0027866. Epub 2011 Nov 16. PLoS One. 2011. PMID: 22114715 Free PMC article.

3

Hepatitis C virus (HCV)-induced suppressor of cytokine signaling (SOCS) 3 regulates proinflammatory TNF-α responses.

Collins AS, Ahmed S, Napoletano S, Schroeder M, Johnston JA, Hegarty JE, O'Farrelly C, Stevenson NJ. Collins AS, et al. Among authors: hegarty je. J Leukoc Biol. 2014 Aug;96(2):255-63. doi: 10.1189/jlb.2A1211-608RRRR. Epub 2014 Mar 21. J Leukoc Biol. 2014. PMID: 24659790 Clinical Trial.

4

In vitro blood cell responsiveness to IFN-α predicts clinical response independently of IL28B in hepatitis C virus genotype 1 infected patients.

Bourke NM, O'Neill MT, Sarwar S, Norris S, Stewart S, Hegarty JE, Stevenson NJ, O'Farrelly C. Bourke NM, et al. Among authors: hegarty je. J Transl Med. 2014 Jul 21;12:206. doi: 10.1186/1479-5876-12-206. J Transl Med. 2014. PMID: 25048205 Free PMC article.

5

Chronic hepatitis C infection blocks the ability of dendritic cells to secrete IFN-α and stimulate T-cell proliferation.

Ryan EJ, Stevenson NJ, Hegarty JE, O'Farrelly C. Ryan EJ, et al. Among authors: hegarty je. J Viral Hepat. 2011 Dec;18(12):840-51. doi: 10.1111/j.1365-2893.2010.01384.x. Epub 2011 Mar 14. J Viral Hepat. 2011. PMID: 22093032

6

Hepatitis C virus-specific Th17 cells are suppressed by virus-induced TGF-beta.

Rowan AG, Fletcher JM, Ryan EJ, Moran B, Hegarty JE, O'Farrelly C, Mills KH. Rowan AG, et al. Among authors: hegarty je. J Immunol. 2008 Oct 1;181(7):4485-94. doi: 10.4049/jimmunol.181.7.4485. J Immunol. 2008. PMID: 18802051

7

Variant in CD209 promoter is associated with severity of liver disease in chronic hepatitis C virus infection.

Ryan EJ, Dring M, Ryan CM, McNulty C, Stevenson NJ, Lawless MW, Crowe J, Nolan N, Hegarty JE, O'Farrelly C. Ryan EJ, et al. Among authors: hegarty je. Hum Immunol. 2010 Aug;71(8):829-32. doi: 10.1016/j.humimm.2010.05.007. Epub 2010 May 12. Hum Immunol. 2010. PMID: 20470843

8

Interferon-α suppressed granulocyte colony stimulating factor production is reversed by CL097, a TLR7/8 agonist.

Tajuddin T, Ryan EJ, Norris S, Hegarty JE, O'Farrelly C. Tajuddin T, et al. Among authors: hegarty je. J Gastroenterol Hepatol. 2010 Dec;25(12):1883-90. doi: 10.1111/j.1440-1746.2010.06281.x. J Gastroenterol Hepatol. 2010. PMID: 21092001

9

Rapid, early and sustained virological responses in a cohort of Irish patients treated with pegylated interferon and ribavirin for chronic hepatitis C virus infection.

Sarwar S, Ryan EJ, Iqbal M, McCormick PA, O'Farrelly C, Hegarty J. Sarwar S, et al. Ir J Med Sci. 2012 Mar;181(1):53-8. doi: 10.1007/s11845-011-0775-4. Epub 2011 Oct 29. Ir J Med Sci. 2012. PMID: 22038749

10

Effect of chronic hepatitis C virus infection on bone disease in postmenopausal women.

Nanda KS, Ryan EJ, Murray BF, Brady JJ, McKenna MJ, Nolan N, O'Farrelly C, Hegarty JE. Nanda KS, et al. Among authors: hegarty je. Clin Gastroenterol Hepatol. 2009 Aug;7(8):894-9. doi: 10.1016/j.cgh.2009.01.011. Epub 2009 Jan 24. Clin Gastroenterol Hepatol. 2009. PMID: 19558999

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