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Smooth muscle hyperplasia due to loss of smooth muscle α-actin is driven by activation of focal adhesion kinase, altered p53 localization and increased levels of platelet-derived growth factor receptor-β.
Papke CL, Cao J, Kwartler CS, Villamizar C, Byanova KL, Lim SM, Sreenivasappa H, Fischer G, Pham J, Rees M, Wang M, Chaponnier C, Gabbiani G, Khakoo AY, Chandra J, Trache A, Zimmer W, Milewicz DM. Papke CL, et al. Among authors: khakoo ay. Hum Mol Genet. 2013 Aug 1;22(15):3123-37. doi: 10.1093/hmg/ddt167. Epub 2013 Apr 15. Hum Mol Genet. 2013. PMID: 23591991 Free PMC article.
Cardiomyocyte PDGFR-beta signaling is an essential component of the mouse cardiac response to load-induced stress.
Chintalgattu V, Ai D, Langley RR, Zhang J, Bankson JA, Shih TL, Reddy AK, Coombes KR, Daher IN, Pati S, Patel SS, Pocius JS, Taffet GE, Buja LM, Entman ML, Khakoo AY. Chintalgattu V, et al. Among authors: khakoo ay. J Clin Invest. 2010 Feb;120(2):472-84. doi: 10.1172/JCI39434. Epub 2010 Jan 11. J Clin Invest. 2010. PMID: 20071776 Free PMC article.
Coronary microvascular pericytes are the cellular target of sunitinib malate-induced cardiotoxicity.
Chintalgattu V, Rees ML, Culver JC, Goel A, Jiffar T, Zhang J, Dunner K Jr, Pati S, Bankson JA, Pasqualini R, Arap W, Bryan NS, Taegtmeyer H, Langley RR, Yao H, Kupferman ME, Entman ML, Dickinson ME, Khakoo AY. Chintalgattu V, et al. Among authors: khakoo ay. Sci Transl Med. 2013 May 29;5(187):187ra69. doi: 10.1126/scitranslmed.3005066. Sci Transl Med. 2013. PMID: 23720580 Free PMC article.
44 results